1-bromo-2-((7-phenylhepta-2,4-diyn-1-yl)oxy)benzene | 1477520-19-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-bromo-2-((7-phenylhepta-2,4-diyn-1-yl)oxy)benzene
• 英文别名: 1-(o-bromophenoxy)-7-phenyl-2,4-heptadiyne；1-Bromo-2-(7-phenylhepta-2,4-diynoxy)benzene；1-bromo-2-(7-phenylhepta-2,4-diynoxy)benzene
• CAS: 1477520-19-6
• 化学式: C₁₉H₁₅BrO
• 分子量: 339.231
• InChiKey: CXAQWKFXVODWEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-bromo-2-((7-phenylhepta-2,4-diyn-1-yl)oxy)benzene 在 一氯化碘 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以88%的产率得到8-bromo-3-iodo-4-(2-iodo-3,4-dihydronaphthalen-1-yl)-2H-chromene
  参考文献：
  名称：

  ICl-Mediated Intramolecular Twofold Iodoarylation of Diynes and Diynyl Diethers and Amines: Synthesis of Bis(2H-hydronaphthalene and chromene) and 2H-Quinoline Bearing an Alkenyl Iodide Moiety

  摘要：

  Electrophilic intramolecular twofold iodoarylation was developed from the reaction of diynes and diynyl diethers and amines with iodine monochloride under mild conditions, which produced bis(2H-hydronaphthalene and chromene) and 2H-quinoline bearing an alkenyl iodide moiety in good to excellent yields. These compounds underwent Pd-catalyzed cross-coupling reactions with arylboronic acid and indium tris(arylthiolate) to produce the functionalized styrene derivatives.

  DOI：

  10.1021/jo401922b
• 作为产物：
  描述：

  2-溴苯酚 在 吡啶 、 四甲基乙二胺 、 氧气 、 potassium carbonate 、 copper(l) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-bromo-2-((7-phenylhepta-2,4-diyn-1-yl)oxy)benzene
  参考文献：
  名称：

  ICl-Mediated Intramolecular Twofold Iodoarylation of Diynes and Diynyl Diethers and Amines: Synthesis of Bis(2H-hydronaphthalene and chromene) and 2H-Quinoline Bearing an Alkenyl Iodide Moiety

  摘要：

  Electrophilic intramolecular twofold iodoarylation was developed from the reaction of diynes and diynyl diethers and amines with iodine monochloride under mild conditions, which produced bis(2H-hydronaphthalene and chromene) and 2H-quinoline bearing an alkenyl iodide moiety in good to excellent yields. These compounds underwent Pd-catalyzed cross-coupling reactions with arylboronic acid and indium tris(arylthiolate) to produce the functionalized styrene derivatives.

  DOI：

  10.1021/jo401922b

文献信息

• ICl-Mediated Intramolecular Twofold Iodoarylation of Diynes and Diynyl Diethers and Amines: Synthesis of Bis(2<i>H</i>-hydronaphthalene and chromene) and 2<i>H</i>-Quinoline Bearing an Alkenyl Iodide Moiety
  作者：Juntae Mo、Wonseok Choi、Jiae Min、Cheol-Eui Kim、Dahan Eom、Sung Hong Kim、Phil Ho Lee

  DOI：10.1021/jo401922b

  日期：2013.11.15

  Electrophilic intramolecular twofold iodoarylation was developed from the reaction of diynes and diynyl diethers and amines with iodine monochloride under mild conditions, which produced bis(2H-hydronaphthalene and chromene) and 2H-quinoline bearing an alkenyl iodide moiety in good to excellent yields. These compounds underwent Pd-catalyzed cross-coupling reactions with arylboronic acid and indium tris(arylthiolate) to produce the functionalized styrene derivatives.