4-乙氧基-3-甲基吡啶 | 101870-21-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-乙氧基-3-甲基吡啶
• 英文名称: 4-Ethoxy-β-picolin
• 英文别名: 4-Ethoxy-3-methylpyridine
• CAS: 101870-21-7
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: CPKZPQVZRHKKPO-UHFFFAOYSA-N

物化性质

• 沸点：
  208.5±20.0 °C(Predicted)
• 密度：
  0.983±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for preparing substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
  申请人：Peterson J. Matthew

  公开号：US20060094878A1

  公开（公告）日：2006-05-04

  Processes and intermediates for preparing substituted 4-amino-1-(pyridylmethyl)-piperidine and related compounds in high yield and high purity are described. The substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds prepared by the described processes are useful as muscarinic receptor antagonists.

  描述了制备高产率和高纯度的取代4-氨基-1-(吡啶甲基)-哌啶和相关化合物的过程和中间体。由所述过程制备的取代4-氨基-1-(吡啶甲基)哌啶和相关化合物可用作毒蕈碱受体拮抗剂。
• Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
  申请人：Mammen Mathai

  公开号：US20080091034A1

  公开（公告）日：2008-04-17

  This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.

  本发明提供了4-氨基-1-(吡啶甲基)哌啶及其相关化合物和药学上可接受的盐，它们可用作毒蕈碱受体拮抗剂。本发明还提供了含有这些化合物的制药组合物；用于制备这些化合物的有用中间体和过程；以及使用这些化合物治疗由毒蕈碱受体介导的疾病状态，例如过度活跃的膀胱、肠易激综合征和慢性阻塞性肺疾病的方法。
• SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：Theravance, Inc.

  公开号：EP1556372B1

  公开（公告）日：2007-05-30
• NEW COMPOUNDS
  申请人：Engelhardt Harald

  公开号：US20100222331A1

  公开（公告）日：2010-09-02

  The present invention encompasses compounds of general Formula (1) wherein R 2 , R 3 , Q, W, X, Y and Z are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
• US7285564B2
  申请人：——

  公开号：US7285564B2

  公开（公告）日：2007-10-23