5-Chloro-3-isopropyl-1-methyl-4-pyrazole carboxaldehyde | 1043918-77-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Chloro-3-isopropyl-1-methyl-4-pyrazole carboxaldehyde
• 英文别名: 5-chloro-3-isopropyl-1-methyl-1H-pyrazole-4-carbaldehyde；5-chloro-1-methyl-3-(propan-2-yl)-1H-pyrazole-4-carbaldehyde；5-chloro-1-methyl-3-propan-2-ylpyrazole-4-carbaldehyde
• CAS: 1043918-77-9
• 化学式: C₈H₁₁ClN₂O
• mdl: MFCD11185414
• 分子量: 186.641
• InChiKey: UKQGPFHWTAMXCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-Isopropyl-1-methyl-5-pyrazolone 以35%的产率得到5-Chloro-3-isopropyl-1-methyl-4-pyrazole carboxaldehyde
  参考文献：
  名称：

  Pyrazoles active in the central nervous system

  摘要：

  本发明涉及式为##STR1##的吡唑化合物，其中R.sub.1为氢、低碳基或苯基，R.sub.2为氢或低碳基，R.sub.3为烷氧基或羟基，R.sub.4为低碳基，以及其药学上可接受的酸加盐。该化合物主要用作抗精神病药物。例如，它们表现出中枢神经系统活性，作为抗精神分裂症药物。

  公开号：

  US04226877A1

文献信息

• PYRAZOLE COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2128138A1

  公开（公告）日：2009-12-02

  The present invention aims to provide an agent for the prophylaxis or treatment of diabetes, which has a superior hypoglycemic action, and is associated with a fewer side effects such as body weight gain and the like. The present invention relates to an agent for the prophylaxis or treatment of diabetes comprising a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof.

  本发明旨在提供一种用于预防或治疗糖尿病的药物，具有优越的降血糖作用，并且与较少的副作用，如体重增加等相关。本发明涉及一种用于预防或治疗糖尿病的药物，包括由以下式表示的化合物：其中每个符号如描述中所定义，或其盐，或其前药。
• FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATES
  申请人：Bartels Guenter

  公开号：US20120065164A1

  公开（公告）日：2012-03-15

  The present invention relates to pyrazole carboxamides derivatives of formula (1) wherein Y represents CR 5 or N, T represents S or O, X1 and X2 represent a chlorine or a fluorine atom, and Z1 represents a substituted or non-substituted cyclopropyl; Their process of preparation, their use as fungicide, and/or anti-mycotoxin active agents, and/or insecticide, and/or nematicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

  本发明涉及式(1)的吡唑羧酰胺衍生物，其中Y代表CR5或N，T代表S或O，X1和X2代表氯或氟原子，Z1代表取代或未取代的环丙基；它们的制备方法，它们作为杀菌剂和/或抗真菌毒素活性剂和/或杀虫剂和/或线虫剂的用途，特别是作为杀菌剂组合物的形式，以及使用这些化合物或组合物控制植物病原真菌，尤其是植物的方法。
• FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATIVES
  申请人：BARTELS Guenter

  公开号：US20140148411A1

  公开（公告）日：2014-05-29

  The present invention relates to pyrazole carboxamides derivatives of formula (1) wherein Y represents CR 5 or N, T represents S or O, X1 and X2 represent a chlorine or a fluorine atom, and Z1 represents a substituted or non-substituted cyclopropyl; Their process of preparation, their use as fungicide, and/or anti-mycotoxin active agents, and/or insecticide, and/or nematicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

  本发明涉及式（1）的吡唑羧酰胺衍生物，其中Y表示CR5或N，T表示S或O，X1和X2表示氯或氟原子，Z1表示取代或未取代的环丙基；它们的制备方法，它们作为杀真菌剂、/或抗霉毒素活性剂、/或杀虫剂、/或杀线虫剂的用途，特别是作为真菌杀剂组合物的形式，以及使用这些化合物或组合物控制植物病原真菌，尤其是植物的方法。
• N-[(HET)ARYLALKYL)] PYRAZOLE(THIO)CARBOXAMIDES AND THEIR HETEROSUBSTITUTED ANALOGUES
  申请人：Benting Jurgen

  公开号：US20130079302A1

  公开（公告）日：2013-03-28

  The present invention relates to fungicidal N-[(het)arylalkyl)]pyrazolecarboxamide or thiocarboxamide and their heterosubstituted analogues, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.

  本发明涉及杀真菌剂N-[(het)arylalkyl)]pyrazolecarboxamide或thiocarboxamide及其杂基取代衍生物，其制备过程和制备中间体化合物，其作为杀真菌剂的用途，特别是以杀真菌剂组合物的形式和使用这些化合物或其组合物控制植物的植物病原真菌的方法。
• N-BENZYL HETEROCYCLIC CARBOXAMIDES
  申请人：Benting Jurgen

  公开号：US20130210864A1

  公开（公告）日：2013-08-15

  The present invention relates to N-benzyl heterocyclic carboxamides derivatives or their thiocarboxamides derivatives, their process of preparation, their use as fungicide, particularly in the form of compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

  本发明涉及N-苄基杂环羧酰胺衍生物或其硫代羧酰胺衍生物，它们的制备方法，它们作为杀菌剂的用途，特别是以组合物形式出现的杀菌剂，以及使用这些化合物或组合物控制植物病原真菌，尤其是植物的方法。