trans-2-Methylcyclohexylmethylaether | 1129265-57-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-2-Methylcyclohexylmethylaether
• 英文别名: 2e-Methyl-1e-methoxycyclohexan；(1S,2S)-1-methoxy-2-methylcyclohexane
• CAS: 1129265-57-1
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: QDLQQFYNFWYKPM-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE
  申请人：Mita Takeshi

  公开号：US20090312330A1

  公开（公告）日：2009-12-17

  An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A 1 , A 2 and A 3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C 1 -C 6 haloalkyl, etc., Y is halogen atm, C 1 -C 6 alkyl, etc., R 1 is C 1 -C 12 alkyl arbitrarily substituted with R 16 , C 3 -C 12 alkenyl, arbitrarily substituted with R 16 is oxygen atom or sulfur atom, —N(R 20 )R 19 , etc., R 2 is hydrogen atom, C 1 -C 4 alkoxy C 1 -C 6 alkyl, etc., R 3 is C 1 -C 6 haloalkyl, etc., R 16 is halogen atom, cyano, phenyl substituted with (Z) p1 , D-1 to D-60, E-1 to E-49, etc., R 19 is phenyl, phenyl substituted with (Z) p1 , etc., R 20 is hydrogen atom, C 1 -C 6 alkyl, etc., Z is halogen atom, nitro, C 1 -C 4 alkoxy, etc., D-1 to D-60 are 5- or 6-membered aromatic heterocyclic rings, E-1 to E-49 are 5- or 6-membered saturated heterocyclic rings, m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

  一种公式（1）的异氧杂环取代苯甲酰胺化合物或其盐： 其中，A1，A2和A3独立地是碳原子或氮原子，G是苯环等，X是卤素原子，C1-C6卤代烷基等，Y是卤素原子，C1-C6烷基等，R1是任意取代R16的C1-C12烷基，任意取代R16的C3-C12烯基，是氧原子或硫原子，-N（R20）R19等，R2是氢原子，C1-C4烷氧基C1-C6烷基等，R3是C1-C6卤代烷基等，R16是卤素原子，氰基，苯基，其上取代有（Z）p1，D-1至D-60，E-1至E-49等，R19是苯基，其上取代有（Z）p1等，R20是氢原子，C1-C6烷基等，Z是卤素原子，硝基，C1-C4烷氧基等，D-1至D-60是5-或6-成员芳香杂环，E-1至E-49是5-或6-成员饱和杂环，m是0至5的整数，n是0至4的整数，p1是1至5的整数。含有这些化合物的杀虫剂。
• ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150031713A1

  公开（公告）日：2015-01-29

  The present invention is directed to benzoquinazilinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

  本发明涉及公式（I）的苯并喹唑啉酮化合物，其为M1受体正向变构调节剂，并且在治疗M1受体参与的疾病，例如阿尔茨海默病、精神分裂症、疼痛或睡眠障碍方面具有用途。该发明还涉及包含该化合物的制药组合物，以及使用该化合物和组合物治疗由M1受体介导的疾病方面的用途。
• Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
  申请人：Lycera Corporation

  公开号：US10442798B2

  公开（公告）日：2019-10-15

  The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

  本发明提供了四氢喹啉磺酰胺化合物、四氢萘磺酸化合物和相关化合物、药物组合物、促进RORy活性的方法、增加受试者体内IL-17含量的方法，以及使用此类化合物治疗癌症和其他疾病的方法。
• Isoxazoline-substituted benzamide compound and pesticide
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US10874645B2

  公开（公告）日：2020-12-29

  A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

  式 (4) 的取代烯基苯化合物： 其中 X1 选自由卤素原子、-SF5、C1-C6 卤代烷基、C1-C6 卤代烷基羟基、C1-C6 卤代烷氧基、C1-C6 卤代烷基、C3-C8 卤代烷基、C1-C6 卤代烷氧基、C1-C3 卤代烷氧基、C1-C6 卤代烷基硫基、C1-C6 卤代烷基亚磺酰基和 C1-C6 卤代烷基磺酰基组成的组；X3 选自由氢原子、卤素原子、氰基、硝基、C1-C6-烷基、C1-C6-卤代烷基、C1-C6-烷氧基和 C1-C6 烷硫基组成的组；X4 选自由氢原子、卤素原子、氰基、C1-C4-烷基、C1-C4-烷氧基和 C1-C4 卤代烷氧基组成的组；R3 是-C(R3a)(R3b)R3c，其中 R3a 和 R3b 各自是卤素原子，或 R3a 和 R3b 通过形成 C2-C5 卤代亚烷基链与连接它们的碳原子一起形成 3 至 6 元环，R3c 选自氢原子、卤素原子、C1-C5 烷基、C1-C5 卤代烷基、C1-C4 卤代烷氧基和 C1-C4 卤代烷硫基组成的组、但条件是，如果 X1 是氟原子、氯原子或三氟甲基，而 X2 和 X3 都是氢原子，如果 X1 和 X2 都是氟原子，而 X3 是氢原子、在 X1 和 X2 均为三氟甲基且 X3 为氢原子的情况下，R3c 为氢原子、氯原子、溴原子、碘原子、C1-C5 烷基、C1-C5 卤代烷基、C1-C4 卤代烷氧基或 C1-C4 卤代烷硫基。
• LIQUID CRYSTAL COMPOSITION AND REFLECTIVE DISPLAY ELEMENT
  申请人：KATO Takashi

  公开号：US20100227084A1

  公开（公告）日：2010-09-09

  A liquid crystal composition includes a dichroic dye represented by Formula (1) below, a nematic liquid crystal and at least two chiral reagents. R 1 to R 8 each independently represent a hydrogen atom or a substituent, in which at least one of R 1 to R 8 represents a substituent represented by -(Het) m -(B 1 ) p -(Q 1 ) q -(B 2 ) r } n —C 1 . A reflective display element electrodes at least one of which is a transparent electrode, and a liquid crystal layer placed between the pair of electrodes and containing the liquid crystal composition.