Z-Tyr-Pro-Gln-Ot-Bu | 406712-27-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Tyr-Pro-Gln-Ot-Bu
• CAS: 406712-27-4
• 化学式: C₃₁H₄₀N₄O₈
• 分子量: 596.681
• InChiKey: NEYIHYIVJLZVFL-SDHOMARFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.31
• 重原子数：
  43.0
• 可旋转键数：
  12.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  177.36
• 氢给体数：
  4.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  Z-Tyr-Pro-Gln-Ot-Bu 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  摘要：

  Peptide Leu-Val-Cys-Tyr-Pro-Gln, identical to the bone marrow peptide MP-3, and its Val(3) and Ser(3) analogs, lacking SH group, were synthesized by conventional methods of peptide chemistry in solution and, along with the MP-3 S-S-dimerization product, were studied with respect to their effect on the macrophage phagocytic activity. It was shown that the activity was only enhanced by peptide MP-3, which demonstrated the essential role of the SH group in this function. The dimer analog of MP-3, unlike dimer analogs of other monocycteine-containing peptides, glutathione and HP5b, did not exhibit the inhibitory effect.

  DOI：

  10.1023/a:1012901200640
• 作为产物：
  描述：

  Z-Pro-Gln-OBut 在 palladium on activated charcoal N-羟基丁二酰亚胺 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 Z-Tyr-Pro-Gln-Ot-Bu
  参考文献：
  名称：

  摘要：

  Peptide Leu-Val-Cys-Tyr-Pro-Gln, identical to the bone marrow peptide MP-3, and its Val(3) and Ser(3) analogs, lacking SH group, were synthesized by conventional methods of peptide chemistry in solution and, along with the MP-3 S-S-dimerization product, were studied with respect to their effect on the macrophage phagocytic activity. It was shown that the activity was only enhanced by peptide MP-3, which demonstrated the essential role of the SH group in this function. The dimer analog of MP-3, unlike dimer analogs of other monocycteine-containing peptides, glutathione and HP5b, did not exhibit the inhibitory effect.

  DOI：

  10.1023/a:1012901200640