2-Chlor-4-pentadecylcyclohexanon | 65148-96-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Chlor-4-pentadecylcyclohexanon
• 英文别名: 2-Chloro-4-pentadecylcyclohexan-1-one
• CAS: 65148-96-1
• 化学式: C₂₁H₃₉ClO
• 分子量: 342.993
• InChiKey: GNGJFXOBHHHEPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Chlor-4-pentadecylcyclohexanon 在 lithium aluminium tetrahydride 、 sodium 、 苯甲醇 作用下， 以 乙醚 为溶剂， 生成 1-Hydroxymethyl-3-pentadecylcyclopentan
  参考文献：
  名称：

  Hypotensive phospholipids. Some stable analogs of Darmstoff

  摘要：

  2-Pentadecyl-4-hydroxymethyl-1,3-dioxolane monosodium phosphate (1) has been shown to exhibit bradycardia and hypotension in rats. It is, however, unstable in aqueous solution. In this study, the stable analogues of 1, 2-pentadecyl-5-hydroxymethyltetrahydrofuran monosodium phosphate (7), and 1-hydroxymethyl-3-pentadecylcyclopentane monosodium phosphate (17) were prepared. These substances exhibited cardiovascular effects similar both qualitively and quantitatively to those elicited by 1 and were stable in solution for about 24 and at least 72 h, respectively.

  DOI：

  10.1021/jm00201a001
• 作为产物：
  描述：

  4-Pentadecylcyclohexanon 在 磺酰氯 作用下， 以 四氯化碳 为溶剂， 生成 2-Chlor-4-pentadecylcyclohexanon
  参考文献：
  名称：

  Hypotensive phospholipids. Some stable analogs of Darmstoff

  摘要：

  2-Pentadecyl-4-hydroxymethyl-1,3-dioxolane monosodium phosphate (1) has been shown to exhibit bradycardia and hypotension in rats. It is, however, unstable in aqueous solution. In this study, the stable analogues of 1, 2-pentadecyl-5-hydroxymethyltetrahydrofuran monosodium phosphate (7), and 1-hydroxymethyl-3-pentadecylcyclopentane monosodium phosphate (17) were prepared. These substances exhibited cardiovascular effects similar both qualitively and quantitatively to those elicited by 1 and were stable in solution for about 24 and at least 72 h, respectively.

  DOI：

  10.1021/jm00201a001