ribostamycin 6'-N-(R)-(3-((2-((2-amino-2-oxohexyl)thio)ethyI)amino)-3-oxopropyl)-2,4-dihydroxy-3,3-dimethylbutanamide | 1391349-97-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ribostamycin 6'-N-(R)-(3-((2-((2-amino-2-oxohexyl)thio)ethyI)amino)-3-oxopropyl)-2,4-dihydroxy-3,3-dimethylbutanamide
• 英文别名: (2R)-N-[3-[2-[6-[[(2R,3S,4R,5R,6R)-5-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxy-3,4-dihydroxyoxan-2-yl]methylamino]-6-oxohexyl]sulfanylethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
• CAS: 1391349-97-5
• 化学式: C₃₄H₆₄N₆O₁₅S
• 分子量: 828.979
• InChiKey: LJXZRCMIVMZIFP-KDDYAYEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6
• 重原子数：
  56
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  389
• 氢给体数：
  14
• 氢受体数：
  19

文献信息

• COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
  申请人：Auclair Karine

  公开号：US20140038914A1

  公开（公告）日：2014-02-06

  This invention relates to a compound of Formula 1A: or a pharmaceutically acceptable salt thereof; wherein R1 to R4, R7, R9 to R12 and Y are as defined herein. The invention further relates to pharmaceutical composition comprising said compound or a pharmaceutically acceptable salt thereof; and method of using same for reducing or reversing bacterial resistance to at least one aminoglycoside antibiotic.
• US9127035B2
  申请人：——

  公开号：US9127035B2

  公开（公告）日：2015-09-08