NHS-glutaryl-N-methylethylenediamine-(ON 013100) | 1013422-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: NHS-glutaryl-N-methylethylenediamine-(ON 013100)
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 5-[2-[[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenoxy]carbonyl-methylamino]ethylamino]-5-oxopentanoate
• CAS: 1013422-79-1
• 化学式: C₃₂H₃₉N₃O₁₃S
• 分子量: 705.74
• InChiKey: LNUJRHNKLSJKTP-DTQAZKPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  49
• 可旋转键数：
  19
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  202
• 氢给体数：
  1
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以74%的产率得到NHS-glutaryl-N-methylethylenediamine-(ON 013100)
  参考文献：
  名称：

  WO2008/33475

  摘要：

  公开号：

文献信息

• ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS
  申请人：Fegley Glenn

  公开号：US20100022615A1

  公开（公告）日：2010-01-28

  Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.

  本发明涉及一种激活的细胞毒性化合物，用于附着于靶向分子治疗哺乳动物疾病状况，包括激活剂、间隔连接剂、连接剂（例如自解性连接剂）和从AMINO-SUBSTITUTED（E）-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES、AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES和SUBSTITUTED PHENOXY-AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES组成的细胞毒性药物。本发明还涉及附着于靶向分子的激活的细胞毒性化合物，其中靶向分子从抗体、受体、配体、细胞因子、激素和信号转导分子等组成的群体中选择。本发明进一步涉及一种治疗疾病状况的方法。
• US8273787B2
  申请人：——

  公开号：US8273787B2

  公开（公告）日：2012-09-25
• [EN] ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS<br/>[FR] COMPOSÉS CYTOTOXIQUES ACTIVÉS DESTINÉS À SE FIXER À DES MOLÉCULES DE CIBLAGE DANS LE TRAITEMENT DE MALADIES TOUCHANT DES MAMMIFÈRES
  申请人：ONCONOVA THERAPEUTICS INC

  公开号：WO2008033475A2

  公开（公告）日：2008-03-20

  [EN] Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND- HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.
  [FR] La présente invention concerne des composés cytotoxiques activés destinés à se fixer à des molécules de ciblage, dans le traitement de maladies touchant des mammifères. Lesdits composés comprennent un activateur, un espaceur-lieur, un lieur (auto-immolant, par exemple), et un médicament cytotoxique choisi dans le groupe constitué des BENZYLSULFONES AMINO-SUBSTITUÉES (E)-2,6-DIALCOXYSTYRYLE 4-SUBSTITUÉES, des STYRYLSULFONANILIDES AMINO- ET HYDROXY-SUBSTITUÉS, et des DÉRIVÉS de PHÉNOXY- ET DE PHÉNYLTHIO-STYRYLSULFONE SUBSTITUÉES. Dans le cas des composés cytotoxiques activés fixés à la molécule de ciblage décrits ici, ladite molécule de ciblage est choisie dans le groupe constitué essentiellement d'un anticorps, d'un récepteur, d'un ligand, d'une cytokine, d'une hormone, et d'une molécule de transmission de signal. L'invention concerne en outre un procédé de traitement de maladies.
• WO2008/33475
  申请人：——

  公开号：——

  公开（公告）日：——