The present invention discloses an etomidate derivative of Formula 1, or a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, a pharmaceutical composition and a kit comprising the same, as well as intermediates and methods for preparing the same, and use thereof. The etomidate derivative of the present invention not only has good anesthetic activity, rapid onset, and short duration of action, but also shows little inhibition to the secretion of corticosteroids in animals, and therefore has both favorable anesthetic effect and safety profiles.
本发明公开了一种式1的
依托咪酯衍
生物,或其药学上可接受的盐、多晶型或溶解物,一种药物组合物和包含其的试剂盒,以及制备其的中间体和方法及其用途。本发明的
依托咪酯衍
生物不仅麻醉活性好、起效快、作用时间短,而且对动物体内皮质类
固醇的分泌几乎没有抑制作用,因此具有良好的麻醉效果和安全性。