phenyl(5-phenyl-2-(1-phenylvinyl)-2H-1,2,3-triazol-4-yl)methanone | 1186338-97-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: phenyl(5-phenyl-2-(1-phenylvinyl)-2H-1,2,3-triazol-4-yl)methanone
• 英文别名: Phenyl-[5-phenyl-2-(1-phenylethenyl)triazol-4-yl]methanone
• CAS: 1186338-97-5
• 化学式: C₂₃H₁₇N₃O
• 分子量: 351.407
• InChiKey: RYPMNMWWEPNCMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯乙炔 、 phenyl(5-phenyl-1H-1,2,3-triazol-4-yl)methanone 在 三苯基膦氯金 、 silver trifluoromethanesulfonate 作用下， 以 甲苯 为溶剂， 以84%的产率得到phenyl(5-phenyl-2-(1-phenylvinyl)-2H-1,2,3-triazol-4-yl)methanone
  参考文献：
  名称：

  Highly efficient synthesis of vinyl substituted triazoles by Au(I) catalyzed alkyne activation

  摘要：

  Au(I) catalyzed 1,2,3-triazole addition to non-activated alkyne was reported. A large group of substituted NH-1,2,3-triazoles were suitable for this transformation along with both internal and terminal alkynes. The N-1 and N-2 vinyl substituted 1,2,3-triazoles were prepared in up to 98% yield with as low as 0.2% catalyst loading, thereby providing a new protocol for the synthesis of potentially biological-active vinyl-triazole building blocks. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.096