6-(diethylaminomethyl)-(2R,3R)-dihydroquercetin | 1426657-65-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6-(diethylaminomethyl)-(2R,3R)-dihydroquercetin
• CAS: 1426657-65-9
• 化学式: C₂₀H₂₃NO₇
• 分子量: 389.405
• InChiKey: ULGVJHRQYPYRQX-VQTJNVASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.03
• 重原子数：
  28.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  130.69
• 氢给体数：
  5.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 二乙胺 、 花旗松素 生成 6-(diethylaminomethyl)-(2R,3R)-dihydroquercetin
  参考文献：
  名称：

  Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives

  摘要：

  Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).

  DOI：

  10.1134/s1068162012030028