(1S,4S,7aS)-4-[3-[tert-butyl(dimethyl)silyl]oxypropyl]-4,7a-dimethyl-1-[(2-methylpropan-2-yl)oxy]-1,2,6,7-tetrahydroinden-5-one | 135395-27-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,4S,7aS)-4-[3-[tert-butyl(dimethyl)silyl]oxypropyl]-4,7a-dimethyl-1-[(2-methylpropan-2-yl)oxy]-1,2,6,7-tetrahydroinden-5-one
• CAS: 135395-27-6
• 化学式: C₂₄H₄₄O₃Si
• 分子量: 408.697
• InChiKey: JZVOJKIWRIMAKS-OYDLWJJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.68
• 重原子数：
  28.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  (+)-(1S,7aS)-1-t-Butoxy-4-(3-t-butyldimethylsiloxypropyl)-7,7a-dihydro-7a-methylindan-5(6H)-one 、 碘甲烷 生成 (1S,4S,7aS)-4-[3-[tert-butyl(dimethyl)silyl]oxypropyl]-4,7a-dimethyl-1-[(2-methylpropan-2-yl)oxy]-1,2,6,7-tetrahydroinden-5-one
  参考文献：
  名称：

  IHARA, MASATAKA;TOKUNAGA, YUJI;TANIGUCHI, NOBUAKI;FUKUMOTO, KEIICHIRO;KAB+, J. ORG. CHEM., 56,(1991) N8, C. 5281-5285

  摘要：

  DOI：

文献信息

• A novel approach to angular triquinanes via intramolecular 1,3-dipolar cycloaddition of nitrile oxide
  作者：Masataka Ihara、Yuji Tokunaga、Nobuaki Taniguchi、Keiichiro Fukumoto、Chizuko Kabuto

  DOI：10.1021/jo00018a014

  日期：1991.8

  The framework of angular triquinane sesquiterpenes was stereoselectively constructed via the intramolecular 1,3-dipolar cycloaddition of nitrile oxide precursors. Optically active indandione 9 was converted into olefinic oximes 18A and 18B through two successive alkylations, followed by ring contraction. Oxidation of the mixture 18A and 18B with sodium hypochlorite gave rise to tetracyclic isoxazolines 21A and 21B, which were transformed into tricyclo[6.3.0.0(4,8)]undecanes 28 and 29.