2,2,3-Trimethylcyclobutanol | 22556-26-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,3-Trimethylcyclobutanol
• 英文别名: 2,2,3-Trimethylcyclobutan-1-ol
• CAS: 22556-26-9
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: INZOOXLPRMJESJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS
  申请人：Evotec International GmbH

  公开号：EP2917185B1

  公开（公告）日：2017-05-10
• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
  申请人：Arvinas, Inc.

  公开号：US20170327469A1

  公开（公告）日：2017-11-16

  The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds Androgen Receptor such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of Androgen Receptor.