(2S,3S,4S)-3-(4-Methoxy-benzyloxy)-2,4-dimethyl-hexane-1,5-diol | 184488-78-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S,3S,4S)-3-(4-Methoxy-benzyloxy)-2,4-dimethyl-hexane-1,5-diol
• CAS: 184488-78-6
• 化学式: C₁₆H₂₆O₄
• 分子量: 282.38
• InChiKey: CAXZWPUPGIZZHZ-BEHMWDDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  20.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (2S,3S,4S)-3-(4-Methoxy-benzyloxy)-2,4-dimethyl-hexane-1,5-diol 在 六甲基磷酰三胺 、 四(三苯基膦)钯 、 草酰氯 、 Jones oxidant 、 pH 7 buffer 、 sodium hexamethyldisilazane 、 二甲基亚砜 、 三乙胺 、 mercury dichloride 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 丙酮 、 乙腈 为溶剂， 反应 0.83h， 生成
  参考文献：
  名称：

  Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization

  摘要：

  Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents to investigate discodermolide's recently discovered ability to bind and stabilize microtubules in cells, Retrosynthetically, the polypropionate is divided into three fragments of approximately equal complexity. This modular strategy provides convergency in the synthesis and facilitates the preparation of discodermolide-based reagents.

  DOI：

  10.1021/ja961374o
• 作为产物：
  描述：

  tert-Butyl-[(2S,3R,4S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-5-enyloxy]-dimethyl-silane 在 二甲基硫 、 臭氧 、 三氟乙酸 作用下， 以 四氢呋喃 为溶剂， 生成 (2S,3S,4S)-3-(4-Methoxy-benzyloxy)-2,4-dimethyl-hexane-1,5-diol
  参考文献：
  名称：

  Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization

  摘要：

  Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents to investigate discodermolide's recently discovered ability to bind and stabilize microtubules in cells, Retrosynthetically, the polypropionate is divided into three fragments of approximately equal complexity. This modular strategy provides convergency in the synthesis and facilitates the preparation of discodermolide-based reagents.

  DOI：

  10.1021/ja961374o