(E)-di(tert-butyl) 3-hexenedioate | 1414926-72-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-di(tert-butyl) 3-hexenedioate
• 英文别名: ditert-butyl (E)-hex-3-enedioate
• CAS: 1414926-72-9
• 化学式: C₁₄H₂₄O₄
• 分子量: 256.342
• InChiKey: BYJHKMHZKXBXTI-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-di(tert-butyl) 3-hexenedioate 在 臭氧 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以100%的产率得到3-氧代丙酸叔丁酯
  参考文献：
  名称：

  An efficient procedure for the synthesis of formylacetic esters

  摘要：

  An efficient synthesis of formylacetic esters via ozonolysis of trans-beta-hydromuconic esters followed by a solid-supported triphenylphosphine reduction has been developed. In addition, an extension toward formylacetic amides and a one-pot preparation of more stable intermediates which can be used for further transformations are also described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.021
• 作为产物：
  描述：

  己-3-烯二酸 在 2,4,6-三甲基吡啶 、 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 苯 为溶剂， 反应 4.5h， 生成 (E)-di(tert-butyl) 3-hexenedioate
  参考文献：
  名称：

  An efficient procedure for the synthesis of formylacetic esters

  摘要：

  An efficient synthesis of formylacetic esters via ozonolysis of trans-beta-hydromuconic esters followed by a solid-supported triphenylphosphine reduction has been developed. In addition, an extension toward formylacetic amides and a one-pot preparation of more stable intermediates which can be used for further transformations are also described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.021

文献信息

• An efficient procedure for the synthesis of formylacetic esters
  作者：Sofie Edvinsson、Susanne Johansson、Andreas Larsson

  DOI：10.1016/j.tetlet.2012.10.021

  日期：2012.12

  An efficient synthesis of formylacetic esters via ozonolysis of trans-beta-hydromuconic esters followed by a solid-supported triphenylphosphine reduction has been developed. In addition, an extension toward formylacetic amides and a one-pot preparation of more stable intermediates which can be used for further transformations are also described. (C) 2012 Elsevier Ltd. All rights reserved.