[6-(4-diethylaminomethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-(3-methyl-benzyl)-amine | 497840-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: [6-(4-diethylaminomethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-(3-methyl-benzyl)-amine
• 英文别名: 6-[4-(diethylaminomethyl)phenyl]-N-[(3-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• CAS: 497840-81-0
• 化学式: C₂₅H₂₉N₅
• 分子量: 399.539
• InChiKey: UXERAPXHQFRZBX-UHFFFAOYSA-N

物化性质

• 密度：
  1.176±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  56.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 7H-pyrrolo[2,3-d]pyrimidine derivatives
  申请人：——

  公开号：US20040248911A1

  公开（公告）日：2004-12-09

  The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I 1 wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.

  这项发明涉及公式I的7H-吡咯[2,3-d]嘧啶衍生物，其中符号和取代基如描述中所定义，以及其制备方法，包括这些衍生物的药物组合物，以及使用这些衍生物—单独或与一个或多个其他药用活性化合物结合—制备用于治疗增生性疾病，如肿瘤的药物组合物。
• 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
  申请人：——

  公开号：US20040242600A1

  公开（公告）日：2004-12-02

  The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour. 1

  本发明涉及式I的7H-吡咯[2,3-d]嘧啶衍生物，其中符号和取代基如描述中所定义，以及制备这些衍生物的方法，包括这些衍生物的制药组合物和使用这些衍生物-单独或与一种或多种其他药理活性化合物结合-制备用于治疗增殖性疾病，如肿瘤的制药组合物。1
• 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
  申请人：Bold Guido

  公开号：US20070161632A1

  公开（公告）日：2007-07-12

  The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.

  本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物，其中符号和取代基的定义如描述所述，以及其制备过程，包括这种衍生物的制药组合物以及使用这种衍生物 - 单独或与一个或多个其他药物活性化合物结合 - 制备用于特别治疗增生性疾病（如肿瘤）的制药组合物。
• US7390805B2
  申请人：——

  公开号：US7390805B2

  公开（公告）日：2008-06-24