tert-butyl (S)-(3-methyl-1-((naphthalen-1-ylmethyl)amino)-1-oxobutan-2-yl)carbamate | 1197279-66-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (S)-(3-methyl-1-((naphthalen-1-ylmethyl)amino)-1-oxobutan-2-yl)carbamate
• 英文别名: tert-butyl N-[(2S)-3-methyl-1-(naphthalen-1-ylmethylamino)-1-oxobutan-2-yl]carbamate
• CAS: 1197279-66-5
• 化学式: C₂₁H₂₈N₂O₃
• 分子量: 356.465
• InChiKey: BRHJXHZWPREWIV-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl (S)-(3-methyl-1-((naphthalen-1-ylmethyl)amino)-1-oxobutan-2-yl)carbamate 在 劳森试剂 作用下， 以 四氢呋喃 为溶剂， 以90%的产率得到C₂₁H₂₈N₂O₂S
  参考文献：
  名称：

  Fine-tuning catalytic activity and selectivity—[Rh(amino acid thioamide)] complexes for efficient ketone reduction

  摘要：

  Amino acid-derived thioamides are prepared and evaluated as ligands in the rhodium-catalyzed asymmetric transfer hydrogenation of ketones in 2-propanol. It is found that increasing the steric bulk at the C-terminus of the ligand had a positive impact on both activity and selectivity in the reduction reaction. In order to find the optimum catalyst, a study is performed on a series of thioamide ligands having substituents of varying size. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.116
• 作为产物：
  描述：

  N-Boc-L-缬氨酸 、 1-萘甲基胺 在 N-甲基吗啉 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 为溶剂， 以35%的产率得到tert-butyl (S)-(3-methyl-1-((naphthalen-1-ylmethyl)amino)-1-oxobutan-2-yl)carbamate
  参考文献：
  名称：

  Fine-tuning catalytic activity and selectivity—[Rh(amino acid thioamide)] complexes for efficient ketone reduction

  摘要：

  Amino acid-derived thioamides are prepared and evaluated as ligands in the rhodium-catalyzed asymmetric transfer hydrogenation of ketones in 2-propanol. It is found that increasing the steric bulk at the C-terminus of the ligand had a positive impact on both activity and selectivity in the reduction reaction. In order to find the optimum catalyst, a study is performed on a series of thioamide ligands having substituents of varying size. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.116

文献信息

• DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES
  申请人：CORNELL UNIVERSITY

  公开号：US20170121366A1

  公开（公告）日：2017-05-04

  The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R 1 -R 10 , X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由以下具有式（I）的化合物表示，其中取代基R1-R10、X、Y、k、m、n、q和s的定义如本文所述。这些化合物用于治疗癌症、免疫紊乱、自身免疫性疾病、神经退行性疾病或炎症性疾病，或用于为移植的器官或组织提供免疫抑制。
• US9988421B2
  申请人：——

  公开号：US9988421B2

  公开（公告）日：2018-06-05
• [EN] DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES<br/>[FR] DIPEPTIDES UTILISÉS EN TANT QU'INHIBITEURS DES IMMUNOPROTÉASOMES HUMAINS
  申请人：UNIV CORNELL

  公开号：WO2015106200A2

  公开（公告）日：2015-07-16

  The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.