2-phenyl-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione | 934353-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-phenyl-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
• 英文别名: 2-Phenyl-1,5,6,7-tetrahydropyrrolo[2,3-c]azepine-4,8-dione；2-phenyl-1,5,6,7-tetrahydropyrrolo[2,3-c]azepine-4,8-dione
• CAS: 934353-34-1
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.261
• InChiKey: XFSPJVIHTZLGBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-phenyl-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione 在 ammonium hydroxide 、 四氯化钛 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 38.75h， 生成 (Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
  参考文献：
  名称：

  Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors

  摘要：

  Natural products have been the subject of interest for drug discovery and as tools for understanding the underlying cellular pathways in various diseases. We present herein the synthesis and evaluation of new analogs of the marine sponge metabolite, debromohymenialdisine, as checkpoint kinase 2 (Chk2) inhibitors. We illustrate herein that slight modifications to the natural product scaffold can induce strong selectivity for Chk2 over Chk1. These Chk2 inhibitors can serve as drug templates or molecular tools to gain insight in Chk2 mediated radioprotection. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.12.054
• 作为产物：
  描述：

  5-苯基-1H-吡咯-2-羧酸 在 sodium hydroxide 、 氯化亚砜 、 phosphorus pentoxide 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 2-phenyl-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
  参考文献：
  名称：

  Synthesis of 2-substituted endo-hymenialdisine derivatives

  摘要：

  The first synthesis of 2-substituted endo-hymenialdisine derivatives 1-4 is described started with 2-substituted pyrroles and 5-substituted pyrrolo-2-carboxylic acids. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2007.01.114

文献信息

• Synthesis of 2-substituted endo-hymenialdisine derivatives
  作者：Qinfei He、Wei Chen、Yong Qin

  DOI：10.1016/j.tetlet.2007.01.114

  日期：2007.3

  The first synthesis of 2-substituted endo-hymenialdisine derivatives 1-4 is described started with 2-substituted pyrroles and 5-substituted pyrrolo-2-carboxylic acids. (c) 2007 Published by Elsevier Ltd.
• Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors
  作者：Rahman Shah Zaib Saleem、Theresa A. Lansdell、Jetze J. Tepe

  DOI：10.1016/j.bmc.2011.12.054

  日期：2012.2

  Natural products have been the subject of interest for drug discovery and as tools for understanding the underlying cellular pathways in various diseases. We present herein the synthesis and evaluation of new analogs of the marine sponge metabolite, debromohymenialdisine, as checkpoint kinase 2 (Chk2) inhibitors. We illustrate herein that slight modifications to the natural product scaffold can induce strong selectivity for Chk2 over Chk1. These Chk2 inhibitors can serve as drug templates or molecular tools to gain insight in Chk2 mediated radioprotection. (C) 2012 Elsevier Ltd. All rights reserved.