(S)-(-)-2,2-dimethyl-5-cyclohexyl-1,3-dioxolan-4-one | 362519-23-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-(-)-2,2-dimethyl-5-cyclohexyl-1,3-dioxolan-4-one
• CAS: 362519-23-1
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: XZKRDEBIAOUXTJ-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  14.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (S)-(-)-2,2-dimethyl-5-cyclohexyl-1,3-dioxolan-4-one 在 氨 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以67%的产率得到(S)-(+)-hexahydromandelamide
  参考文献：
  名称：

  1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines

  摘要：

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00199-9
• 作为产物：
  描述：

  (S)-α-羟基环己烷乙酸 、 2,2-二甲氧基丙烷 以 氯仿 为溶剂， 反应 48.0h， 以99%的产率得到(S)-(-)-2,2-dimethyl-5-cyclohexyl-1,3-dioxolan-4-one
  参考文献：
  名称：

  1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines

  摘要：

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00199-9