Pentafluorbenzoylessigsaeure | 19174-82-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Pentafluorbenzoylessigsaeure
• 英文别名: Pentafluorobenzoylacetic acid；3-oxo-3-(2,3,4,5,6-pentafluorophenyl)propanoic acid
• CAS: 19174-82-4
• 化学式: C₉H₃F₅O₃
• 分子量: 254.113
• InChiKey: SRYKWBWSHVNWHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Aminoquinolones as GSK-3 inhibitors
  申请人：Cociorva Oana

  公开号：US20070254866A1

  公开（公告）日：2007-11-01

  Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases.

  本文提供了氨基喹啉及其药用可接受的衍生物。在某些实施例中，本文提供了用于治疗、预防或改善GSK-3介导疾病的化合物、组合物和方法。
• INFLAMMATORY CYTOKINE RELEASE INHIBITOR
  申请人：MUTO Susumu

  公开号：US20090192122A2

  公开（公告）日：2009-07-30

  A medicament having inhibitory activity against NF-κB activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种具有抑制NF-κB激活活性的药物，其包括以下通式(I)所表示的化合物或其药理学上可接受的盐作为活性成分：其中X代表连接基，A代表氢原子或乙酰基，E代表芳基或杂芳基，环X代表芳烃或杂芳烃。
• Inhibitors against the production and release of inflammatory cytokines
  申请人：——

  公开号：US20040259877A1

  公开（公告）日：2004-12-23

  A medicament having inhibitory activity against NF-&kgr;B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: 1 wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种具有抑制NF-&kgr;B激活活性的药物，其包括以下通式（I）所表示的化合物或其药学上可接受的盐作为活性成分：1其中X表示连接基，A表示氢原子或乙酰基，E表示芳基或杂芳基，环X表示芳烃或杂芳烃。
• Antimicrobial quinolones, their compositions and uses
  申请人：The Procter & Gamble Company

  公开号：US20030008894A1

  公开（公告）日：2003-01-09

  Compounds of the following formula: 1 are effective antimicrobial agents.

  以下公式的化合物：1是有效的抗微生物剂。
• 5,6-Difluoronaphthyridines and 5,6,8-trifluoro-quinolines as antibacterial agents
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0202763A1

  公开（公告）日：1986-11-26

  Novel difluoro-naphthyridine-and trifluoroquinoline-carboxylic acids of formula (I) as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

  描述了作为抗菌剂的新型二氟萘啶和三氟喹啉羧酸的式 (I) 描述了作为抗菌剂的新型二氟萘啶和三氟喹啉羧酸及其制造、配制和用于治疗细菌感染的方法，包括描述了用于制造抗菌剂的某些新型中间体。