6-O-Methansulfonyl-D-galactose | 89886-09-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-O-Methansulfonyl-D-galactose
• 英文别名: [(2R,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl] methanesulfonate
• CAS: 89886-09-9
• 化学式: C₇H₁₄O₈S
• 分子量: 258.249
• InChiKey: NGFBWCCWRRVFQV-WNJXEPBRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-O-Methansulfonyl-D-galactose 、 Alpha-苄基苯基肼 以 甲醇 为溶剂， 生成 6-O-Methansulfonyl-D-galactose-(N-benzyl-phenyl-hydrazon)
  参考文献：
  名称：

  6-O-METHANESULPHONYL-D-GALACTOSE

  摘要：

  不可用。

  DOI：

  10.1139/v63-266
• 作为产物：
  描述：

  1,2:3,4-Di-O-isopropyliden-6-O-methansulfonyl-D-galactose 在 硫酸 作用下， 以 乙醇 为溶剂， 生成 6-O-Methansulfonyl-D-galactose
  参考文献：
  名称：

  6-O-METHANESULPHONYL-D-GALACTOSE

  摘要：

  不可用。

  DOI：

  10.1139/v63-266

文献信息

• MODIFIED GLYCOPROTEIN, PROTEIN-CONJUGATE AND PROCESS FOR THE PREPARATION THEREOF
  申请人：SynAffix B.V.

  公开号：EP2935608A1

  公开（公告）日：2015-10-28
• GLYCOENGINEERED ANTIBODY, ANTIBODY-CONJUGATE AND METHODS FOR THEIR PREPARATION
  申请人：SynAffix B.V.

  公开号：EP2935611A1

  公开（公告）日：2015-10-28
• [EN] MODIFIED GLYCOPROTEIN, PROTEIN-CONJUGATE AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] GLYCOPROTÉINE MODIFIÉE, CONJUGUÉ-PROTÉINE ET SON PROCÉDÉ DE PRÉPARATION
  申请人：SYNAFFIX BV

  公开号：WO2015057063A1

  公开（公告）日：2015-04-23

  The invention relates to a glycoprotein comprising an optionally fucosylated glycan according to formula (105) or (106), wherein Su(A)x is a modified sugar moiety comprising one or more functional groups A. Functional group A is independently selected from the group consisting of a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonated hydroxyacetamido group. The invention also relates to a glycoprotein-conjugate wherein a glycoprotein according to the invention is conjugated to a molecule of interest. Said molecule of interest may for example be an active substance. The invention further relates to a process for the preparation of a modified glycoprotein, and to a method for the preparation of a glycoprotein-conjugate. The invention particularly relates to modified antibodies, antibody-conjugates, antibody-drug conjugates and methods for the preparation thereof.
• [EN] MODIFIED GLYCOPROTEIN, PROTEIN-CONJUGATE AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] GLYCOPROTÉINE MODIFIÉE, CONJUGUÉ PROTÉIQUE ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：SYNAFFIX BV

  公开号：WO2015057064A1

  公开（公告）日：2015-04-23

  The present invention relates to a glycoprotein comprising a glycan of the formula (102), wherein b is 0 or 1, wherein the core GlcNAcresidue of said glycan is optionally fucosylated, wherein Su(A)x is a sugar derivative comprising x functional groups A wherein x is 1, 2, 3 or 4 and A is independently selected from the group consisting of an azido group, a keto group, an alkynyl group, a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonylated hydroxyacetamido group. (Formula (102)), The invention further relates to a protein-conjugate wherein a modified glycoprotein according to the invention is conjugated to a molecule of interest. Said molecule of interest may for example be an active substance. The invention further relates to a process for the preparation of a modified glycoprotein according to the invention, and to a method for the preparation of a protein-conjugate according to the invention. The invention particularly relates to modified antibodies, antibody-conjugates, antibody-drug conjugates (ADCs) and methods for the preparation thereof.
• [EN] GLYCOENGINEERED ANTIBODY, ANTIBODY-CONJUGATE AND METHODS FOR THEIR PREPARATION<br/>[FR] ANTICORPS GLYCOMANIPULÉ, CONJUGUÉ D'ANTICORPS ET PROCÉDÉS POUR LEUR PRÉPARATION
  申请人：SYNAFFIX BV

  公开号：WO2015057065A1

  公开（公告）日：2015-04-23

  The invention relates to glycoengineered antibodies and antibody-conjugates. In particular, the invention relates to an antibody conjugate, prepared from IgG antibody comprising at least two N-linked glycosylation sites on the combination of a single heavy chain and single light chain. The invention further relates to methods for the preparation of the antibody- conjugates according to the invention.In particular, the invention relates to an antibody-drug conjugate that is conjugated to different toxins, and the a process for the preparation thereof.