香豆素545 | 85642-11-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 香豆素545
• 中文别名: 香豆素 545
• 英文名称: coumarin 545
• 英文别名: 5-(1,3-benzothiazol-2-yl)-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraen-4-one
• CAS: 85642-11-1
• 化学式: C₂₂H₁₈N₂O₂S
• 分子量: 374.463
• InChiKey: WYZWJLZUSHFFOR-UHFFFAOYSA-N

物化性质

• 熔点：
  254 °C
• 溶解度：
  氯仿（微溶、超声处理）、DMSO（微溶、加热、超声处理）
• 最大波长(λmax)：
  477nm(CH3CN)(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  70.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  8-羟基久洛里定 在 哌啶 、 三氯氧磷 作用下， 以 溶剂黄146 、 正丁醇 为溶剂， 反应 3.0h， 生成 香豆素545
  参考文献：
  名称：

  SYNTHESIS OF JULOLIDINE DERIVATIVES

  摘要：

  DOI：

  10.1080/00304940109356622

文献信息

• MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20160018389A1

  公开（公告）日：2016-01-21

  An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

  本发明的一个目的是提供一种利用有机化合物对巨噬细胞亚型进行识别的方法。本发明的另一个目的是提供一种巨噬细胞识别试剂，其中当添加有机化合物时得到的光谱特征取决于巨噬细胞亚型而不同。本发明的另一个目的是提供一种利用巨噬细胞识别试剂进行巨噬细胞亚型评估的方法，一种用于巨噬细胞亚型与测试物之间相关性分析的方法，一种用于巨噬细胞亚型与测试物之间相关性筛选的方法，以及一种试剂盒。提供了一种利用添加有机化合物得到的光谱特征不同取决于巨噬细胞亚型的巨噬细胞亚型识别方法。
• COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：US20210104674A1

  公开（公告）日：2021-04-08

  A compound is represented by Formula 1, where the substitents are as defined in the detailed description. An organic light-emitting device including the compound has high efficiency and improved lifespan compared to an organic light-emitting device including a compound of the related art.

  该化合物由公式1表示，其中取代基如详细描述中所定义。包括该化合物的有机发光器件具有较高的效率和改善的寿命，与包括相关技术中化合物的有机发光器件相比。
• An Iminocoumarin Sulfonamide Based Turn-On Fluorescent Probe for the Detection of Biothiols in Aqueous Solution
  作者：Yan-Ling Yang、Fu-Ming Zhang、Ya-Wen Wang、Bao-Xin Zhang、Ran Fang、Jian-Guo Fang、Yu Peng

  DOI：10.1002/asia.201403056

  日期：2015.2

  A new chemodosimeter for the highly selective sensing and imaging of biothiols was designed and realized in phosphate‐buffered saline solution at pH 7.4 through a fluorescence “off–on” response. A unique mechanism featuring a two‐step cascade (biothiols→H2O) sequence for this remarkable recognition is disclosed for the first time.

  设计了一种新的化学计量仪，用于生物硫醇的高选择性传感和成像，并通过荧光“关-开”响应在pH 7.4的磷酸盐缓冲盐溶液中实现。首次公开了具有两步级联（生物硫醇→H 2 O）序列的独特机制，以实现这种出色的识别。
• POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, POLARIZED LIGHT-EMITTING COATING MATERIAL, NOVEL NAPHTHOLACTAM DERIVATIVE NOVEL COUMARIN DERIVATIVE, NOVEL NILE RED DERIVATIVE, AND NOVEL ANTHRACENE DERIVATIVE
  申请人：Kubota Yusuke

  公开号：US20130334461A1

  公开（公告）日：2013-12-19

  Provided are a polymerizable liquid crystal composition, a coating material, a medium, and a polarizing device each produced using a polymerizable liquid crystal compound and a colorant and each capable of producing polarized light suitable for polarizing devices, and also a novel naphtholactam derivative, a novel coumarin derivative, a novel Nile Red derivative, and a novel anthracene derivative each suitable for use as the colorant. Specifically provided are a polymerizable liquid crystal composition containing (A) at least one liquid crystal compound having a polymerizable functional group, (B) at least one colorant, and (C) a polymerization initiator, and a novel naphtholactam derivative of formula (IV′), a novel coumarin derivative of formula (VI′), a novel Nile Red derivative of formula (VII′), and a novel anthracene derivative of formula (VIII′) each suitable for use as the colorant (B).

  提供了一种可聚合的液晶组合物、涂料材料、介质和极化装置，每种都使用了聚合液晶化合物和颜料，并且能够产生适合于极化装置的偏振光，还提供了一种新型萘内酰胺衍生物、一种新型香豆素衍生物、一种新型尼罗红衍生物和一种新型蒽衍生物，每种都适用于用作颜料。具体提供了一种聚合液晶组合物，包含（A）至少一种具有聚合功能基团的液晶化合物，（B）至少一种颜料，和（C）聚合引发剂，以及一种适用于用作颜料（B）的新型萘内酰胺衍生物（IV′）, 一种新型香豆素衍生物（VI′）, 一种新型尼罗红衍生物（VII′）和一种新型蒽衍生物（VIII′）。
• ORGANIC ELECTROLUMINESCENT DEVICE AND METHOD FOR MANUFACTURE THEREOF
  申请人：Beijing Visionox Technology Co., Ltd.

  公开号：EP3070757A1

  公开（公告）日：2016-09-21

  The present invention discloses an organic electroluminescent device and a manufacturing method thereof. The host material of the light-emitting layer of the organic electroluminescent device is material in which the triplet state energy level of the CT excited state is higher than that of the n-π excited state by 0 to 0.3 eV; or the triplet state of the host material of the light-emitting layer is higher than that of the n-π excited state by more than 1.0 eV; in addition, the difference in energy level between the second triplet state of the n-π state and the first singlet state of the CT excited state is -0.1 to 0.1 eV; and the luminescent dye is a fluorescent dye. With regard to the organic electroluminescent device in the present invention, as new host material in the light-emitting layer is used and the host material has a donor group and an acceptor group, the triplet state in the light-emitting layer may be fully utilized to achieve a 100% light-emitting efficiency in the fluorescent device. Furthermore, no noble metal is required to be used, thus reducing the cost.

  本发明公开了一种有机电致发光器件及其制造方法。有机电致发光器件的发光层的主材料是 CT 激发态的三重态能级比 n-π 激发态的三重态能级高 0 至 0.3 eV；或发光层主材料的三重态比n-π激发态的三重态高1.0 eV以上；此外，n-π态的第二三重态与CT激发态的第一单重态之间的能级差为-0.1至0.1 eV；且发光染料为荧光染料。就本发明的有机电致发光器件而言，由于在发光层中使用了新的宿主材料，且宿主材料具有供体基团和受体基团，因此可以充分利用发光层中的三重态，使荧光器件的发光效率达到 100%。此外，无需使用贵金属，从而降低了成本。