2-(4-fluorophenyl)-4-iodomethyl-5-methyloxazole | 501362-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-fluorophenyl)-4-iodomethyl-5-methyloxazole
• 英文别名: 2-(4-fluorophenyl)-4-(iodomethyl)-5-methyl-1,3-oxazole
• CAS: 501362-66-9
• 化学式: C₁₁H₉FINO
• 分子量: 317.101
• InChiKey: UEJHHKGNCWUBHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-fluorophenyl)-4-iodomethyl-5-methyloxazole 在 二正丁基氧化锡 、 cesium fluoride 作用下， 以 甲苯 、 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 21.0h， 生成 rac-cis-3-[2-(4-fluorophenyl)-5-methyloxazol-4-ylmethoxy]cyclohexanol
  参考文献：
  名称：

  Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals

  摘要：

  环烷基衍生物具有生物等效羧酸基团，其制备方法及其作为药物的用途。本发明涉及具有生物等效羧酸基团的环烷基衍生物及其生理上可接受的盐和生理功能衍生物。所描述的化合物具有下式1,1中所定义的基团，以及它们的生理上可接受的盐和制备方法。这些化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及胰岛素抵抗相关的紊乱。

  公开号：

  US20040198786A1
• 作为产物：
  描述：

  4-iodomethyl-5-phenyl-2-p-tolyloxazole 、 2,3-丁二酮,单肟,(E)- 、 对氟苯甲醛 以gave 2-(4-fluorophenyl)-4-iodomethyl-5-methyloxazole的产率得到2-(4-fluorophenyl)-4-iodomethyl-5-methyloxazole
  参考文献：
  名称：

  Cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals

  摘要：

  本文提供了环烷基取代的氨基酸衍生物，其制备过程以及作为药物的用途。

  公开号：

  US20050215596A1

文献信息

• Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：——

  公开号：US20040122069A1

  公开（公告）日：2004-06-24

  Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.

  披露了二芳基环烷基衍生物及其生理上可接受的盐和生理功能衍生物。这些化合物包括式I,1中定义的基团，以及它们的生理上可接受的盐和制备方法。这些化合物通常具有降脂和/或三酸甘油酯降低作用，并且适用于例如治疗脂质代谢紊乱、II型糖尿病和X综合征等疾病。
• Diarylcycloalkyl derivatives, processes for their preparation and their use s pharmaceuticals
  申请人：——

  公开号：US20030144332A1

  公开（公告）日：2003-07-31

  Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.

  披萨店的员工们正在忙着准备今晚的外卖订单。
• Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US20040209920A1

  公开（公告）日：2004-10-21

  Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl-substituted alkanoic acid derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for the treatment and/or prevention of disorders of the fatty acid metabolism and glucose utilization disorders and also disorders in which insulin resistance is involved.

  芳基环烷基取代的烷基酸衍生物，其制备方法及其作为药物的用途。该发明涉及芳基环烷基取代的烷基酸衍生物及其生理可接受的盐和生理功能衍生物。所描述的化合物为式I，其中基团如所定义，以及其生理可接受的盐和制备方法。这些化合物适用于治疗和/或预防脂肪酸代谢障碍、葡萄糖利用障碍以及胰岛素抵抗相关的疾病。
• 6-OXAZOL-4-YLMETHOLMETHOXY-ALKO-ALKOXYMETHYL SUBSTITUTED BENZOIC ACID DERIVATIVES FORMING PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) LIGANDS, PROCESS FOR THEIR PREPARATION AND METHODS OF USE THEREOF
  申请人：STAPPER Christian

  公开号：US20080171776A1

  公开（公告）日：2008-07-17

  The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptor (PPAR) agonists/antagonists, the invention relates to compounds of formula I wherein R1-R6 are further defined herein.

  本发明涵盖了用于治疗代谢性疾病的化合物和组合物，尤其是血液中与胰岛素相关的代谢性疾病，如高脂血症、糖尿病、胰岛素抵抗等，其中包括带有环己基甲氧基取代基和其盐的乙酸衍生物。作为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂，本发明涉及式I的化合物，其中R1-R6在此进一步定义。
• Cycloalkylmethoxy-substituted acetic acid derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：Stapper Christian

  公开号：US20050101637A1

  公开（公告）日：2005-05-12

  Provided herein are novel compounds of formula I below: in which the radicals are as defined, their physiologically acceptable salts, processes for their preparation, as well as methods of treating and/or preventing disorders of disorders of fatty acid metabolism and glucose utilization disorders, and also of disorders in which insulin resistance is involved, in a patient.

  本文提供了以下公式I的新化合物： 其中基团的定义如下，它们的生理学上可接受的盐，其制备过程，以及治疗和/或预防患者体内脂肪酸代谢和葡萄糖利用障碍，以及胰岛素抵抗相关的障碍的方法。