| 1235973-22-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1235973-22-4
• 化学式: C₃₅H₆₀N₆O₂₃
• 分子量: 932.888
• InChiKey: IHBQLGZNLWVRMY-QIBXHZAHSA-N

反应信息

• 作为产物：
  描述：

  在 水 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Probe design and synthesis of Galβ(1→3)[NeuAcα(2→6)]GlcNAcβ(1→2)Man motif of N-glycan

  摘要：

  Synthesis and clusterization of Gal beta(1 -> 3)[NeuAc alpha(2 -> 6)]GlcNAc beta(1 -> 2)Man motif of the N-glycan, as the molecular probes for their biological evaluation, are reported. Key step is the quantitative and the completely alpha-selective sialylation of the C5-azide N-phenyltrifluoroacetimidate with the disaccharide acceptor, Gal beta(1 -> 3) GlcNTroc. Clusterization of the 16 molecules of trisaccharide motif was also achieved by the 'self-activating click reaction'. These probes could efficiently be labeled by biotin and/or other fluorescenceor radioactive reporter groups through either cross metathesis, acylation, Cu(I)-mediated Huisgen [2+3]-cycloaddition, or the azaelectrocyclization to utilize the various biological techniques. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.04.067