3-(Azetidin-3-yloxy]pyridine-2,2,2-trifluoroacetate | 224818-31-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(Azetidin-3-yloxy]pyridine-2,2,2-trifluoroacetate
• 英文别名: 3-(azetidin-3-yloxy)pyridine;2,2,2-trifluoroacetic acid
• CAS: 224818-31-9
• 化学式: C10H11F3N2O3
• 分子量: 264.2
• InChiKey: LXRYZIFLSLQJER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.07
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3807269A1

  公开（公告）日：2021-04-21
• Cyclic Ureas
  申请人：SIRONAX LTD

  公开号：US20210292305A1

  公开（公告）日：2021-09-23

  The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
• [EN] NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM<br/>[FR] NOUVEAUX DÉRIVÉS D'ISOXAZOLYLE ÉTHER EN TANT QUE GABA A ALPHA5 PAM
  申请人：HOFFMANN LA ROCHE

  公开号：WO2019238633A1

  公开（公告）日：2019-12-19

  The invention provides novel compounds having the general formula (I) or (II) wherein R2, R3, R5, R99, W, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.