| 1356917-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1356917-08-2
• 化学式: C₃₀H₃₁ClFN₇O₂S
• 分子量: 608.139
• InChiKey: ZWYKEVAGWRDVEP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[(3-isopropyl[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}urea 在 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2,2,2]octane-1,4-bis(tetrafluoroborate) 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 50.0h， 以28%的产率得到
  参考文献：
  名称：

  Lead Diversification 2: Application to P38, gMTP and lead compounds

  摘要：

  Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C-H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.033