4-叔丁基-2-苯基噻唑 | 19960-63-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-叔丁基-2-苯基噻唑
• 英文名称: 4-t-Butyl-2-phenylthiazol
• 英文别名: 4-tert-butyl-2-phenylthiazole；Thiazole, 4-(1,1-dimethylethyl)-2-phenyl-；4-tert-butyl-2-phenyl-1,3-thiazole
• CAS: 19960-63-5
• 化学式: C₁₃H₁₅NS
• 分子量: 217.335
• InChiKey: ONZGPCUGXQHYAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  S-(3,3-dimethyl-1-butynyl)thiobenzimidonium tetrafluoroborate 在 sodium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 以9.7 mg的产率得到4-叔丁基-2-苯基噻唑
  参考文献：
  名称：

  通过硫代脲和硫代酰胺的1-炔基（苯基）-λ3-碘酮的环缩合反应合成噻唑。

  摘要：

  DOI：

  10.1002/anie.200502438

文献信息

• Synthesis of Thiazoles and Aminothiazoles from β‐Keto Tosylates under Supramolecular Catalysis in the Presence of β‐Cyclodextrin in Water
  作者：V. Pavan Kumar、M. Narender、R. Sridhar、Y. V. D. Nageswar、K. Rama Rao

  DOI：10.1080/00397910701575913

  日期：2007.11

  Abstract This is the first report on the supramolecular synthesis of thiazoles/aminothiazoles from β‐keto tosylates and thioamide/thiourea in water in the presence of β‐cyclodextrin in impressive yields. Formation of inclusion complexes was explained from 1H NMR studies.

  摘要 这是关于在 β-环糊精存在下从 β-酮甲苯磺酸盐和硫代酰胺/硫脲在水中以令人印象深刻的产率超分子合成噻唑/氨基噻唑的第一份报告。1H NMR 研究解释了包合物的形成。
• Spirohydantoin Aryl Cgrp Receptor Antagonists
  申请人：Bell Ian M.

  公开号：US20090239870A1

  公开（公告）日：2009-09-24

  Compounds of formula I: (wherein variables A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , B, E 1 , E 2 , E 3 , E 4 , E 5 , G 1 , G 2 and R 6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  公式I的化合物：（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2和R6如本文所述），这些化合物是CGRP受体拮抗剂，可用于治疗或预防CGRP参与的疾病，如偏头痛。本发明还涉及包含这些化合物的制药组合物，以及使用这些化合物和组合物在预防或治疗CGRP参与的这些疾病中的应用。
• Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof
  申请人：Fensholdt Jef

  公开号：US20070244117A1

  公开（公告）日：2007-10-18

  The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R 1 , A, R 9 , X, B, R 8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer.

  本发明涉及一般式I的化合物，其中D、E、F、G、W、Y、R1、A、R9、X、B、R8如本文所定义，并且其药学上可接受的盐、水合物或溶剂化物，用于治疗与异常血管生成相关的疾病，如癌症，可单独使用或与一个或多个其他药理活性化合物联合使用。
• Spirolactam aryl cgrp receptor antagonists
  申请人：Bell Ian M.

  公开号：US20090247514A1

  公开（公告）日：2009-10-01

  Compounds of formula I: (wherein variables A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , E 1 , E 2 , E 3 , E 4 , E 5 , G 1 , G 2 , J and K are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  化学式为I的化合物：（其中变量A1、A2、A3、A4、A5、A6、A7、E1、E2、E3、E4、E5、G1、G2、J和K如本文所述）是CGRP受体拮抗剂，可用于治疗或预防CGRP参与的疾病，如偏头痛。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物预防或治疗CGRP参与的疾病的方法。
• Fungicide hydroximoyl-tetrazole derivatives
  申请人：Christian Isabelle

  公开号：US20090291969A1

  公开（公告）日：2009-11-26

  The present invention relates to hydroximoyl-tetrazole derivatives of formula (I) wherein T represent a tetrazolyl substituent, A represents a carbo- or heterocycle, L 1 and L 2 represent various linking groups and Q represents a 5-membered heterocycle, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

  本发明涉及公式（I）的羟肟基四唑衍生物，其中T代表四唑基取代基，A代表碳或杂环，L1和L2代表不同的连接基，Q代表5元杂环，其制备方法，其作为杀真菌活性剂的用途，特别是作为杀真菌组合物的形式，以及使用这些化合物或组合物控制植物病原真菌，尤其是植物的方法。