6-(4-(5-(3-(trifluoromethyl)phenylamino)-1,3,4-oxadiazol-2-yl)phenoxy)-2-(methylthio)pyrimidin-4-amine | 1224846-38-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(4-(5-(3-(trifluoromethyl)phenylamino)-1,3,4-oxadiazol-2-yl)phenoxy)-2-(methylthio)pyrimidin-4-amine
• 英文别名: 5-[4-(6-amino-2-methylsulfanylpyrimidin-4-yl)oxyphenyl]-N-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine
• CAS: 1224846-38-1
• 化学式: C₂₀H₁₅F₃N₆O₂S
• 分子量: 460.439
• InChiKey: LGVIAVOWYPTATO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Heterocyclic Compounds Useful for Kinase Inhibition
  申请人：Amitech Therapeutic Solutions, Inc.

  公开号：US20150158828A1

  公开（公告）日：2015-06-11

  Provided herein are compounds useful for kinase inhibition.

  在此提供了一些用于抑制激酶的化合物。
• HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION
  申请人：Amitech Therapeutics Solutions, Inc.

  公开号：EP2550266B1

  公开（公告）日：2018-05-09
• METHODS FOR BLOCKING CELL PROLIFERATION AND TREATING DISEASES AND CONDITIONS RESPONSIVE TO CELL GROWTH INHIBITION
  申请人：Cheresh David

  公开号：US20130266636A1

  公开（公告）日：2013-10-10

  In alternative embodiments, the invention provides methods for regulating or modulating RAF kinases. In alternative embodiments, the invention provides methods for ameliorating, preventing and/or treating diseases, infections and/or conditions having unwanted, pathological or aberrant cell proliferation, or that are responsive to inhibition or arrest of cell growth, by administration of an allosteric RAF inhibitor and/or any agent which prevents localization of RAF to mitotic spindles or mid-bodies.
• US8957216B2
  申请人：——

  公开号：US8957216B2

  公开（公告）日：2015-02-17
• US9212151B2
  申请人：——

  公开号：US9212151B2

  公开（公告）日：2015-12-15