(1R,3R)-Methyl-hydroxymethylcyclopentan | 64681-38-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1R,3R)-Methyl-hydroxymethylcyclopentan
• 英文别名: (1S,3R)-Methyl-hydroxymethylcyclopentan；Cyclopentanemethanol, 3-methyl-, (1R-trans)-；[(1R,3R)-3-methylcyclopentyl]methanol
• CAS: 64681-38-5
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: PNZNVGRTAKUKGI-RNFRBKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use
  申请人：Greig Iain Robert

  公开号：US20110172189A1

  公开（公告）日：2011-07-14

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc. Formula (I).

  本发明涉及治疗化合物领域，更具体地涉及以下公式的某些芳基-苯基-磺酰胺基环烷化合物（统称为“APSAC化合物”）。本发明还涉及包含这种化合物的制药组合物以及在体内外使用这种化合物和组合物治疗炎症、关节破坏和/或骨质流失等问题，治疗由免疫系统过度和/或不适当和/或持久活化引起的疾病，如类风湿性关节炎、牛皮癣、银屑病性关节炎、慢性阻塞性肺疾病（COPD）、动脉粥样硬化、炎症性肠病、强直性脊柱炎等炎症和自身免疫性疾病，以及与骨质流失相关的疾病，如类风湿性关节炎、骨质疏松症、癌症相关骨病、帕吉特病等，以及癌症，如血液系统恶性肿瘤、实体瘤等。公式（I）。
• ARYL-PHENYL-SULFONAMIDO-CYCLOALKYL COMPOUNDS AND THEIR USE
  申请人：Pimco 2664 Limited

  公开号：EP2344449B1

  公开（公告）日：2015-05-13
• Purine derivatives and methods of use thereof
  申请人：Jagtap Prakash

  公开号：US20070191301A1

  公开（公告）日：2007-08-16

  The present invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's core body temperature, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ophthalmic condition, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.
• HYDROXAMIC ACID DERIVATIVE, METHOD FOR PRODUCING SAME AND USE THEREOF
  申请人：INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US20220033369A1

  公开（公告）日：2022-02-03

  The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.
• US9616037B2
  申请人：——

  公开号：US9616037B2

  公开（公告）日：2017-04-11