trans-2-hydroxy-cis-6-methylcyclohexyl 2,2-dichloroacetate | 1228440-30-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-2-hydroxy-cis-6-methylcyclohexyl 2,2-dichloroacetate
• CAS: 1228440-30-9
• 化学式: C₉H₁₄Cl₂O₃
• 分子量: 241.114
• InChiKey: VDKIRPPLMDXGNZ-FSDSQADBSA-N

反应信息

• 作为反应物：
  描述：

  trans-2-hydroxy-cis-6-methylcyclohexyl 2,2-dichloroacetate 在 三乙烯二胺 作用下， 以 氘代氯仿 为溶剂， 反应 0.08h， 生成 trans-2-hydroxy-trans-3-methylcyclohexyl 2,2-dichloroacetate
  参考文献：
  名称：

  Desymmetrization of meso-1,2-Diols via the Dynamic Kinetic Resolution of Its Monodichloroacetates

  摘要：

  Enantioselective acylation catalyzed by the thioamide modified 1-methylhistidine methyl ester 1 in combination with DABCO-mediated racemization of the substrate led to the efficient dynamic kinetic resolution or meso-1,2-diol monodichloroacetates. In this way, cyclic and acyclic meso-1,2-diol monodichloroacetates can be transformed to the enantiomerically enriched (1S,2R)-heterosubstituted diol diesters which are stable in enantiomerically pure form and can be readily used for further organic transformations.

  DOI：

  10.1021/jo100435f