(12Z,23R,63S,72Z)-11H,71H-1,2,7(3,1),6(1,3)-tetraindolinacyclodecaphane-22,62-dione | 1356833-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (12Z,23R,63S,72Z)-11H,71H-1,2,7(3,1),6(1,3)-tetraindolinacyclodecaphane-22,62-dione
• CAS: 1356833-12-9
• 化学式: C₃₈H₃₂N₄O₂
• 分子量: 576.698
• InChiKey: ZGRKISQTOSJASM-TYHGNQNSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.05
• 重原子数：
  44.0
• 可旋转键数：
  0.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  50.48
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  3-diazo-indolin-2-one 在 dirhodium tetraacetate 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 (12Z,23R,63S,72Z)-11H,71H-1,2,7(3,1),6(1,3)-tetraindolinacyclodecaphane-22,62-dione 、 (1S,21S)-9,13,28,32-tetrazanonacyclo[30.6.1.12,9.113,20.121,28.03,8.014,19.022,27.033,38]dotetraconta-2(42),3,5,7,14,16,18,20(41),22,24,26,33,35,37-tetradecaene-39,40-dione
  参考文献：
  名称：

  Rhodium(II) catalyzed intermolecular double C-alkylation: a method for the synthesis of tetraindoles and indolophanes

  摘要：

  Double C-alkylation of cyclic diazoamides or bis-diazoamides with indoles or bis-indoles has been achieved to synthesize tetraindole derivatives using rhodium(II) acetate as a catalyst under mild reaction conditions with complete regioselectivity. The intermolecular double C-alkylation reaction strategy was successfully applied to synthesize indolophanes in moderate yield with excellent regiocontrol. The structure and stereochemistry of macrocycles were unequivocally confirmed with the help of single-crystal X-ray structure analyses. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.073