1-(2,6-Dichlorophenyl)imidazolidin-2-one | 185116-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-(2,6-Dichlorophenyl)imidazolidin-2-one
• CAS: 185116-65-8
• 化学式: C₉H₈Cl₂N₂O
• 分子量: 231.081
• InChiKey: SDWDRGIGFRGCJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-哌啶酰氯 、 1-(2,6-Dichlorophenyl)imidazolidin-2-one 在 sodium 作用下， 生成 1-(2,6-dichlorophenyl)-3-(piperidine-1-carbonyl)imidazolidin-2-one
  参考文献：
  名称：

  Matosiuk; Kulinski; Tkaczynski, Acta poloniae pharmaceutica, 1996, vol. 53, # 1, p. 75 - 77

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二氯苯胺 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 16.5h， 生成 1-(2,6-Dichlorophenyl)imidazolidin-2-one
  参考文献：
  名称：

  New Substituted 1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl Derivatives with α₂-Adrenoceptor Antagonist Activity

  摘要：

  The emergence of a novel theory concerning the role of noradrenaline in the progression and the treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases has provided a new impetus toward the discovery of novel compounds acting at alpha(2)-adrenoceptors. A series of substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl) piperidin-4-yl derivatives bearing an amide, urea, or imidazolidinone moiety was studied. Some members of this series of compounds proved to be potent alpha(2)-adrenoceptor antagonists with good selectivity versus alpha(1)-adrenergic and D(2)-dopamine receptors. Particular emphasis is given to compound 33g which displays potent alpha(2)-adrenoceptor binding affinity in vitro and central effects in vivo following oral administration.

  DOI：

  10.1021/jm991121g

文献信息

• New Substituted 1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl Derivatives with α₂-Adrenoceptor Antagonist Activity
  作者：Patrice Mayer、Pascale Brunel、Céline Chaplain、Christel Piedecoq、Francis Calmel、Philippe Schambel、Philippe Chopin、Thierry Wurch、Petrus J. Pauwels、Marc Marien、Jean-Louis Vidaluc、Thierry Imbert

  DOI：10.1021/jm991121g

  日期：2000.10.1

  The emergence of a novel theory concerning the role of noradrenaline in the progression and the treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases has provided a new impetus toward the discovery of novel compounds acting at alpha(2)-adrenoceptors. A series of substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl) piperidin-4-yl derivatives bearing an amide, urea, or imidazolidinone moiety was studied. Some members of this series of compounds proved to be potent alpha(2)-adrenoceptor antagonists with good selectivity versus alpha(1)-adrenergic and D(2)-dopamine receptors. Particular emphasis is given to compound 33g which displays potent alpha(2)-adrenoceptor binding affinity in vitro and central effects in vivo following oral administration.
• Matosiuk; Kulinski; Tkaczynski, Acta poloniae pharmaceutica, 1996, vol. 53, # 1, p. 75 - 77
  作者：Matosiuk、Kulinski、Tkaczynski

  DOI：——

  日期：——