N-methyl-O-[3-(perfluorooctyl)propyl]-2-deoxy-2-acetylamino-N-(β-D-glucopyranosyl)hydroxylamine | 1011478-33-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-methyl-O-[3-(perfluorooctyl)propyl]-2-deoxy-2-acetylamino-N-(β-D-glucopyranosyl)hydroxylamine
• CAS: 1011478-33-3
• 化学式: C₂₀H₂₃F₁₇N₂O₆
• 分子量: 710.385
• InChiKey: HCMXEOWZMPRPCJ-LZQZFOIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.58
• 重原子数：
  45.0
• 可旋转键数：
  14.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  111.49
• 氢给体数：
  4.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  N-acetylglucosamine 、 N-methyl-3-(perfluorooctyl)propylhydroxylamine 以 乙腈 为溶剂， 生成 N-methyl-O-[3-(perfluorooctyl)propyl]-2-deoxy-2-acetylamino-N-(β-D-glucopyranosyl)hydroxylamine
  参考文献：
  名称：

  Synthesis of Fluorous Tags for Incorporation of Reducing Sugars into a Quantitative Microarray Platform

  摘要：

  Carbohydrate microarrays can map out key interactions of carbohydrates and proteins in a high-throughput manner, but require the inclusion of a range of sugars for their optimal use. Here we present the synthesis and use of a new hydroxylamine-modified fluorous tag that allows the facile incorporation of reducing sugars into a noncovalent fluorous-based microarray after simple purification by fluorous solid-phase extraction (FSPE). The microarray supports quantitative screening against carbohydrate-binding proteins.

  DOI：

  10.1021/ol702915e