N-[(1E)-{(2S)-2-[(methoxymethoxy)methyl]piperidin-1-yl}(phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine | 1217352-77-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: N-[(1E)-{(2S)-2-[(methoxymethoxy)methyl]piperidin-1-yl}(phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine
• CAS: 1217352-77-6
• 化学式: C₂₁H₃₄N₂O₃
• 分子量: 362.513
• InChiKey: XRZSJRMGEIEAJE-AXBCGQFQSA-N

反应信息

• 作为产物：
  描述：

  N-[(1E)-[2-[(methoxymethoxy)methyl]pyridin-1(2H)-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine 在 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 N-[(1E)-{(2S)-2-[(methoxymethoxy)methyl]piperidin-1-yl}(phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine 、 N-[(1E)-{(2R)-2-[(methoxymethoxy)methyl]piperidin-1-yl}(phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine
  参考文献：
  名称：

  Stereoselective Syntheses of l-Pipecolic Acid and (2S,3S)-3-Hydroxypipecolic Acid from a Chiral N-Imino-2-phenyl-1,2-dihydropyridine Intermediate

  摘要：

  Stereoselective syntheses of L-pipecolic acid and (2S,3S)3-hydroxypipecolic acid were achieved from a chiral N-imino-2-phenyl-1,2-dlhydropyridine intermediate. The 3-hydroxy substituent of the latter amino acid was introduced by hetero-Diels-Alder reaction of singlet oxygen with the 1,2-dihydropyridine.

  DOI：

  10.1021/jo902527s