2-methoxy-4-(tosyloxy)anisole | 137669-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-4-(tosyloxy)anisole
• 英文别名: 3,4-dimethoxyphenyl tosylate；3,4-Dimethoxyphenyl 4-methylbenzene-1-sulfonate；(3,4-dimethoxyphenyl) 4-methylbenzenesulfonate
• CAS: 137669-14-8
• 化学式: C₁₅H₁₆O₅S
• 分子量: 308.355
• InChiKey: AFEUZGHTWOZDBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-methoxy-4-(tosyloxy)anisole 在 1,1'-双(二苯基膦)二茂铁 、 bis(acetylacetonato)palladium(II) 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以88%的产率得到4-(3,4-二甲氧基苯基)-1,2-二甲氧基苯
  参考文献：
  名称：

  钯在室温下通过裂解C‑O键的方式催化芳基磺酸盐的还原均偶联反应

  摘要：

  在温和条件下已成功实现了钯催化的芳基磺酸盐还原均偶联反应。这种转变是芳基磺酸盐在室温下通过C-O键断裂的均偶联反应的新方法，从而提供了对称性联芳基的另一种合成方法。所报道的还原性均偶联反应对许多常见的官能团均具有耐受性，而与给电子或吸电子性质无关，这使得这种新近发展的转变对于补充乌尔曼偶联很重要。

  DOI：

  10.1002/aoc.3705
• 作为产物：
  描述：

  2,4-bis(tosyloxy)anisole 在 potassium tert-butylate 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成 2-methoxy-4-(tosyloxy)anisole
  参考文献：
  名称：

  The regioselective cleavage of aryl tosylates by electrochemical reduction

  摘要：

  The electrochemical reductions of eight bis(tosyloxy)benzanoid compounds were studied as a method for the regioselective cleavage of aryl tosylates. For the methyl bis(tosyloxy)benzoate isomers, a strong preference was observed for cleavage of the tosyl group in conjugation with the electron-withdrawing ester moiety. Thus it was possible to selectively cleave tosyl groups to the ortho or para positions over tosyl groups at the meta positions. The bis(tosyloxy)anisole isomers displayed the opposite regioselectivity favoring cleavage of tosyl groups that were meta to the electron-donating methoxy substituent. The general electrochemical process for the reduction of aryl tosylates has been shown to be selective, high yielding, and reproducible on gram quantities.

  DOI：

  10.1021/jo00029a010

文献信息

• Iron-Catalyzed Coupling of Aryl Sulfamates and Aryl/Vinyl Tosylates with Aryl Grignards
  作者：Toolika Agrawal、Silas P. Cook

  DOI：10.1021/ol5024344

  日期：2014.10.3

  The iron-catalyzed coupling of aryl sulfamates and tosylates with aryl Grignard reagents is reported for the first time. The methodology employs air-stable, low-cost FeF3 center dot 3H(2)O and the N-heterocyclic carbene ligand IPr center dot HCl as the preligand to form a long-lived catalyst upon treatment with aryl Grignards. The reaction provides a range of cross-coupled products in good-to-excellent yields. In contrast to previous reports with aryl chlorides, these reactions proceed with low levels of Grignard homocoupling regardless of the iron source.
• Palladium Catalyzed Arylation and Benzylation of Nitroarenes Using Aryl Sulfonates and Benzyl Acetates
  作者：Zubaoyi Yi、Yodit Aschenaki、Ryan Daley、Stephen Davick、Abigail Schnaith、Rylee Wander、Dipannita Kalyani

  DOI：10.1021/acs.joc.7b00550

  日期：2017.7.7

  Pd-catalyzed arylation or benzylation of nitroazoles using aryl sulfonates or benzyl acetates is described. Electronically varied aryl tosylates and mesylates, as well as benzyl acetates, afford the arylated and benzylated products. Arylation of nitrobenzene is also reported. The relative rate for the arylation of halides is greater than that of tosylates using the reported reaction parameters. These studies enhance the scope of electrophiles for nitroarene arylations and benzylations, which was hitherto limited to the use of halide electrophiles.
• Ligands for metals and improved metal-catalyzed processes based thereon
  申请人：Massachusetts Institute of Technology (MIT)

  公开号：EP2583958B1

  公开（公告）日：2016-08-10
• US7223879B2
  申请人：——

  公开号：US7223879B2

  公开（公告）日：2007-05-29
• Palladium-catalyzed reductive homocoupling of aryl sulfonates via cleavage of C─O bond at room temperature
  作者：Shuangling Zhong、Mengxin Chen、Ge Liu、Chenggang Sun、Wencong Liu

  DOI：10.1002/aoc.3705

  日期：2017.9

  homocoupling of aryl sulfonates has been successfully achieved under mild conditions. This transformation is a new method for the homocoupling reaction of aryl sulfonates at room temperature via the cleavage of C─O bonds, thus providing an alternative synthesis of symmetric biaryls. The reported reductive homocoupling reaction is tolerant of many common functional groups regardless of electron‐donating or

  在温和条件下已成功实现了钯催化的芳基磺酸盐还原均偶联反应。这种转变是芳基磺酸盐在室温下通过C-O键断裂的均偶联反应的新方法，从而提供了对称性联芳基的另一种合成方法。所报道的还原性均偶联反应对许多常见的官能团均具有耐受性，而与给电子或吸电子性质无关，这使得这种新近发展的转变对于补充乌尔曼偶联很重要。