ethyl 4-(benzyloxy)-6-methylindole-2-carboxylate | 65751-97-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl 4-(benzyloxy)-6-methylindole-2-carboxylate
• 英文别名: 4-Benzyloxy-6-methyl-1H-indole-2-carboxylic acid ethyl ester；Ethyl 4-(benzyloxy)-6-methyl-1H-indole-2-carboxylate；ethyl 6-methyl-4-phenylmethoxy-1H-indole-2-carboxylate
• CAS: 65751-97-5
• 化学式: C₁₉H₁₉NO₃
• 分子量: 309.365
• InChiKey: RPNOVLRYIWAXHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 4-(benzyloxy)-6-methylindole-2-carboxylate 在 喹啉 、 水 、 铜 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 16.0h， 生成 4-苄氧基-6-甲基吲哚
  参考文献：
  名称：

  [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF PREPARATION THEREOF
  [FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS PROCÉDÉS DE PRÉPARATION

  摘要：

  This disclosure relates to heterocyclic compounds of Formula (I), Formula (II), and Formula (III) as well as the preparation and use thereof. As contemplated herein, heterocyclic compounds of Formula (I), Formula (II), and Formula (III) may be used for the treatment of neuropsychiatric, and neurodegenerative, neuroinflammatory and pain disorders including depression, as well as tobacco, opiate, and cocaine addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain syndromes including cluster headaches and chemotherapy induced peripheral neuropathy. Formula (I), Formula (II), Formula (III)

  公开号：

  WO2022246554A1
• 作为产物：
  描述：

  2-羟基-4-甲基苯甲醛 在 三氟乙酸乙酯 、 sodium 、 sodium hydride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 甲苯 、 mineral oil 为溶剂， 反应 17.17h， 生成 ethyl 4-(benzyloxy)-6-methylindole-2-carboxylate
  参考文献：
  名称：

  [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF PREPARATION THEREOF
  [FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS PROCÉDÉS DE PRÉPARATION

  摘要：

  This disclosure relates to heterocyclic compounds of Formula (I), Formula (II), and Formula (III) as well as the preparation and use thereof. As contemplated herein, heterocyclic compounds of Formula (I), Formula (II), and Formula (III) may be used for the treatment of neuropsychiatric, and neurodegenerative, neuroinflammatory and pain disorders including depression, as well as tobacco, opiate, and cocaine addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain syndromes including cluster headaches and chemotherapy induced peripheral neuropathy. Formula (I), Formula (II), Formula (III)

  公开号：

  WO2022246554A1

文献信息

• Aminopropanol substituted indole compounds and compositions for the
  申请人：Boehringer Mannheim GmbH

  公开号：US04229464A1

  公开（公告）日：1980-10-21

  New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, and R.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.

  新的氨基丙醇化合物的化学式为##STR1## 其中R是较低的烷基，环烷基或烷基硫醇基，R.sub.1是氢或较低的烷基，羟基烷基，皮瓦酰氧基烷基，烷氧基烷基，烷氧羰基，羧基或--CONR.sub.3 R.sub.4，其中R.sub.3和R.sub.4可以相同或不同，表示氢或较低的烷基，R.sub.2是较低的烷基，羟基烷基，烷氧基烷基或皮瓦酰氧基烷基，或者当R是烷基硫醇基或R.sub.1是皮瓦酰氧基烷基时，R.sub.2也可以是氢，以及其药学上可接受的盐; 在治疗或预防心脏和循环疾病方面具有显著的疗效。
• SUBSTITUTED INDOLE-O-GLUCOSIDES
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1680131A2

  公开（公告）日：2006-07-19
• EP1680131A4
  申请人：——

  公开号：EP1680131A4

  公开（公告）日：2009-05-27
• Substituted indole-O-glucosides
  申请人：Beavers Pat Mary

  公开号：US20050037981A1

  公开（公告）日：2005-02-17

  Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
• Substituted indazole-O-glucosides
  申请人：Urbanski Maud

  公开号：US20060293251A1

  公开（公告）日：2006-12-28

  Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.