1,3,3-Tribenzyl-oxindol | 14192-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,3,3-Tribenzyl-oxindol
• 英文别名: 1,3,3-Tribenzylindolin-2-one；1,3,3-tribenzylindol-2-one
• CAS: 14192-30-4
• 化学式: C₂₉H₂₅NO
• 分子量: 403.524
• InChiKey: WTMNHTUNGDPCBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-吲哚酮 、 氯化苄 在 乙醇 、 sodium ethanolate 作用下， 生成 1,3,3-Tribenzyl-oxindol
  参考文献：
  名称：

  Oxindolylalanine

  摘要：

  DOI：

  10.1021/jo50014a011

文献信息

• Mirtazapine, but not fluvoxamine, normalizes the blunted REM sleep response to clonidine in depressed patients: implications for subsensitivity of alpha2-adrenergic receptors in depression
  作者：Michel Schittecatte、Françoise Dumont、Robert Machowski、Eric Fontaine、Catherine Cornil、Julien Mendlewicz、Jean Wilmotte

  DOI：10.1016/s0165-1781(01)00362-6

  日期：2002.1

  To determine whether alpha(2)-adrenergic receptor (alpha(2)AR) subsensitivity is a state or a trait marker of depression, we consecutively challenged 32 drug-free depressed patients with a clonidine REM suppression test (CREST). We then treated the patients with fluvoxamine, a selective serotonin reuptake inhibitor, or mirtazapine, a selective alpha(2)-adrenergic receptor antagonist. The First 10 patients from each treatment group who recovered were given a second challenge test. The CREST values of the two treatment groups at each time point were compared, and also compared with the CREST values of a group of 10 normal subjects. Before treatment, the REM sleep response to clonidine in the two groups of patients was significantly blunted compared with the REM sleep response in the healthy subjects. After treatment, there was still an abnormal REM sleep response to clonidine in the fluvoxamine-treated patients, despite clinical recovery, but there was a normalized REM sleep response in the mirtazapine-treated patients. These results are compatible with the hypothesis that alpha(2)AR subsensitivity is a trait marker of depression and suggest that the effects of these two antidepressants on alpha(2)AR sensitivity may not be linked to the alleviation of depression. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.