4-Methyl-5-phenyl-4-imidazolin-2-thion | 23187-10-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Methyl-5-phenyl-4-imidazolin-2-thion
• 英文别名: 4-Phenyl-5-methyl-Δ⁴-imidazolin-thion-(2)；5-Methyl-4-phenyl-4-imidazolin-2-thion；4-methyl-5-phenyl-1,3-dihydro-imidazole-2-thione；4-Methyl-5-phenyl-1,3-dihydro-imidazol-2-thion；5-methyl-4-phenyl-1H-imidazole-2-thiol；4-methyl-5-phenyl-1,3-dihydroimidazole-2-thione
• CAS: 23187-10-2
• 化学式: C₁₀H₁₀N₂S
• mdl: MFCD09063664
• 分子量: 190.269
• InChiKey: IPAKKGNEAWAPJQ-UHFFFAOYSA-N

物化性质

• 熔点：
  290-295 °C
• 沸点：
  310.6±45.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Methyl-5-phenyl-4-imidazolin-2-thion 、 硝酸 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Gabriel, Chemische Berichte, 1908, vol. 41, p. 1927

  摘要：

  DOI：
• 作为产物：
  描述：

  potassium thioacyanate 、 alkaline earth salt of/the/ methylsulfuric acid 生成 4-Methyl-5-phenyl-4-imidazolin-2-thion
  参考文献：
  名称：

  Gabriel, Chemische Berichte, 1908, vol. 41, p. 1927

  摘要：

  DOI：

文献信息

• Behr-Bregowski, Chemische Berichte, 1897, vol. 30, p. 1521
  作者：Behr-Bregowski

  DOI：——

  日期：——
• METHIMAZOLE DERIVATIVES AND TAUTOMERIC CYCLIC THIONES TO TREAT AUTOIMMUNE DISEASES
  申请人：Sentron Medical, Inc.

  公开号：EP1112072A2

  公开（公告）日：2001-07-04
• [EN] METHIMAZOLE DERIVATIVES AND TAUTOMERIC CYCLIC THIONES TO TREAT AUTOIMMUNE DISEASES<br/>[FR] DERIVES DE METHIMAZOLE ET THIONES CYCLIQUES TAUTOMERES PERMETTANT DE TRAITER LES MALADIES AUTO-IMMUNES
  申请人：SENTRON MEDICAL INC

  公开号：WO2000012175A2

  公开（公告）日：2000-03-09

  The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. These methods utilize specifically-defined methimazole derivatives and tautomeric cyclic thione compounds, as well as pharmaceutical compositions containing those compounds. These compounds and compositions have been found to be at least as effective as methimazole in terms of pharmaceutical activity, while having less of an adverse effect on thyroid function. They are also more soluble in conventional pharmaceutical vehicles than methimazole. An assay for screening the activity of compounds useful against autoimmune diseases (ability to suppress expression of MHC Class I and II molecules) is also taught.
• [EN] IMMUNE ACTIVATION BY DOUBLE-STRANDED POLYNUCLEOTIDES<br/>[FR] ACTIVATION DE SYSTEME IMMUNITAIRE AU MOYEN DE POLYNUCLEOTIDES BICATENAIRES
  申请人：——

  公开号：WO2000015768A9

  公开（公告）日：2000-08-31

  [EN] Double-stranded polynucleotide activates the expression of immune recognition molecules. The polynucleotide can have a minimal length and activates the expression of molecules not encoded by a nucleotide sequence that is not necessarily related to the polynucleotide. The present invention provides for a simple and specific system to activate expression of Class I and/or Class II molecules of the major histocompatibility complex (MHC), and allows regulation of expression of MHC molecules on the cell-surface of antigen presenting cells and other immune cells. Also provided are systems for the screening, identification, and isolation of compounds that increase or decrease this activation.
  [FR] L'invention concerne un polynucléotide bicaténaire permettant d'activer l'expression des molécules de la reconnaissance immunitaire. Le polynucléotide de l'invention, qui peut être de longueur minimale, active l'expression de molécules non codées par une séquence nucléotidique qui n'est pas nécessairement associée au polynucléotide. La présente invention concerne un système simple et spécifique permettant d'activer l'expression des molécules de la classe I et/ou II du complexe majeur d'histocompatibilité, et de réguler l'expression de ces molécules à la surface des cellules porteuse d'antigènes et autres cellules immunitaires. L'invention concerne enfin des systèmes de criblage, d'identification et d'isolement de composés favorisant ou ralentissant cette activation.