(5-phenoxy-2-{(S)-4-(2-oxopiperazin-4-yl)ethyl-4,5-dihydrothiazol-2-yl}-1H-indol-7-yl)cyclopentylamine | 1120344-50-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5-phenoxy-2-{(S)-4-(2-oxopiperazin-4-yl)ethyl-4,5-dihydrothiazol-2-yl}-1H-indol-7-yl)cyclopentylamine
• 英文别名: 4-{2-[(S)-2-(7-cyclopentylamino-5-phenoxy-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethyl}-piperazin-2-one；4-[2-[(4S)-2-[7-(cyclopentylamino)-5-phenoxy-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-4-yl]ethyl]piperazin-2-one
• CAS: 1120344-50-4
• 化学式: C₂₈H₃₃N₅O₂S
• 分子量: 503.668
• InChiKey: CGHUTNQOIIDFJE-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：Kim Soon Ha

  公开号：US20100267708A1

  公开（公告）日：2010-10-21

  The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.

  本发明涉及公式（1）的新化合物，表现出对葡萄糖激酶的优异活性，并且包括该化合物作为活性成分的药物组合物。
• PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND
  申请人：Kim Soon Ha

  公开号：US20120214804A1

  公开（公告）日：2012-08-23

  The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.

  本发明涉及一种药物组合物，其包含规范中定义的化合物的化学式(1)、(2)或(3)，用于预防或治疗与氧化应激、线粒体功能障碍、缺氧损伤、坏死和/或缺血再灌注损伤相关的疾病，以及一种具有抗氧化作用的吲哚化合物的化妆品组合物。
• Pharmaceutical composition comprising indole compound
  申请人：LG CHEM, LTD.

  公开号：US10322135B2

  公开（公告）日：2019-06-18

  The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.

  本发明涉及一种药物组合物，该药物组合物包含说明书中定义的式(1)、(2)或(3)化合物，用于预防或治疗与氧化应激、线粒体功能障碍、缺氧损伤、坏死和/或缺血再灌注损伤相关的疾病，以及一种化妆品组合物，该化妆品组合物包含具有抗氧化作用的吲哚化合物。
• US8309586B2
  申请人：——

  公开号：US8309586B2

  公开（公告）日：2012-11-13
• [EN] GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT<br/>[FR] ACTIVATEURS DE LA GLUCOKINASE ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES DERNIERS EN TANT QU'INGRÉDIENT ACTIF
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2009082152A2

  公开（公告）日：2009-07-02

  The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.