3,4,6-tri-O-acetyl-2-azido-2-deoxy-α/β-D-glucopyranosyl trichloroacetimidate | 1330067-77-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α/β-D-glucopyranosyl trichloroacetimidate
• 英文别名: 2-deoxy-2-azido-3-O-benzyl-4,6-di-O-acetyl-D-glucopyranosyl trichloroacetimidate；[(2R,3S,4R,5R)-3-acetyloxy-5-azido-4-phenylmethoxy-6-(2,2,2-trichloroethanimidoyl)oxyoxan-2-yl]methyl acetate
• CAS: 1330067-77-0
• 化学式: C₁₉H₂₁Cl₃N₄O₇
• 分子量: 523.757
• InChiKey: FBAZKXUFOTZGDK-RZJWPAKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  3,4,6-tri-O-acetyl-2-azido-2-deoxy-α/β-D-glucopyranosyl trichloroacetimidate 、 allyl 2-O-benzyl-3-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-4-O-(3,4,6-tri-O-benzyl-β-D-glucopyranosyl)-6-O-(4-methoxyphenyl)-α-D-glucopyranoside 在 三氟甲磺酸三甲基硅酯 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 0.92h， 生成
  参考文献：
  名称：

  [EN] SYNTHETIC OLIGOSACCHARIDES FOR MORAXELLA VACCINE
  [FR] OLIGOSACCHARIDES SYNTHÉTIQUES POUR VACCINS CONTRE MORAXELLA

  摘要：

  公开号：

  WO2011137181A8

文献信息

• Synthesis of the essential core of the human glycosylphosphatidylinositol (GPI) anchor
  作者：Barbara Richichi、Lucio Luzzatto、Rosario Notaro、Giancarlo la Marca、Cristina Nativi

  DOI：10.1016/j.bioorg.2010.12.002

  日期：2011.4

  role of GPI anchors is of paramount importance; however, we are still far from fully understanding the structure–function relationship of these molecules. One major limiting factor has been the tiny quantities available from natural sources; obtaining homogeneous and well-defined GPI structures by synthesis, is both a challenge and an attractive goal. We report here the convergent synthesis of the essential

  GPI锚的生物学作用至关重要。然而，我们离完全了解这些分子的结构-功能关系还很远。一个主要的限制因素是可从自然资源中获得的微量产品。通过合成获得均质且定义明确的GPI结构，既是挑战，也是诱人的目标。我们在这里报告人类GPI锚点1的基本核心的收敛合成，利用共同的前体获得三糖供体2和新的保护基序列。首次制备的最终产品具有生物活性。
• Synthetic Oligosaccharides for Moraxella Vaccine
  申请人：CAMPBELL A. Stewart

  公开号：US20140148592A1

  公开（公告）日：2014-05-29

  The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.

  本发明提供了基于合成Moraxella catarrhalis脂多糖（LOS）的寡糖和共轭物，其中包含各种M. catarrhalis血清型特异性寡糖抗原或对应于给定血清型内的三种主要血清型和/或成员的各种核心M. catarrhalis寡糖结构或基序。这些寡糖可以通过化学组装方法合成，该方法依赖于有限数量的单糖和二糖构建块。本发明还提供了基于M. catarrhalis LOS的免疫原和免疫保护组合物以及由此产生的抗体，用于诊断、治疗和预防由M. catarrhalis引起的感染。
• SYNTHETIC OLIGOSACCHARIDES FOR MORAXELLA VACCINE
  申请人：VISTERRA, INC.

  公开号：US20160375120A1

  公开（公告）日：2016-12-29

  The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.
• US8716469B2
  申请人：——

  公开号：US8716469B2

  公开（公告）日：2014-05-06
• US9447133B2
  申请人：——

  公开号：US9447133B2

  公开（公告）日：2016-09-20