3-(allyl(tert-butoxycarbonyl)amino)propyl 1H-imidazole-1-carboxylate | 1606141-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(allyl(tert-butoxycarbonyl)amino)propyl 1H-imidazole-1-carboxylate
• 英文别名: 3-[(2-Methylpropan-2-yl)oxycarbonyl-prop-2-enylamino]propyl imidazole-1-carboxylate
• CAS: 1606141-58-5
• 化学式: C₁₅H₂₃N₃O₄
• 分子量: 309.365
• InChiKey: YFSOIGSSYSCFTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  73.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(allyl(tert-butoxycarbonyl)amino)propyl 1H-imidazole-1-carboxylate 在 potassium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 30.0h， 生成 3-Prop-2-enyl-1,3-oxazinan-2-one
  参考文献：
  名称：

  Thermally induced substrate release via intramolecular cyclizations of Amino esters and Amino carbonates

  摘要：

  The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 degrees C was observed only for the seven-membered ring progenitors. Applicability of the approach was illustrated by delta-lactam formation within a poly(dimethylsiloxane) microchannel for release of a captured fluorescent probe. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.092
• 作为产物：
  描述：

  N,N'-羰基二咪唑 、 叔丁基烯丙基(3-羟丙基)氨基甲酸酯 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以95%的产率得到3-(allyl(tert-butoxycarbonyl)amino)propyl 1H-imidazole-1-carboxylate
  参考文献：
  名称：

  Thermally induced substrate release via intramolecular cyclizations of Amino esters and Amino carbonates

  摘要：

  The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 degrees C was observed only for the seven-membered ring progenitors. Applicability of the approach was illustrated by delta-lactam formation within a poly(dimethylsiloxane) microchannel for release of a captured fluorescent probe. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.092

文献信息

• NANOPARTICLES FOR DRUG DELIVERY
  申请人：KNIPP Ralph J.

  公开号：US20150374849A1

  公开（公告）日：2015-12-31

  The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery.

  本发明提供了纳米颗粒、制备纳米颗粒的方法以及使用纳米颗粒的方法。药物输送系统的一个重要属性是其能够允许空间和时间调节药物释放，从而最大限度地减少副作用并提高传统药物的治疗效果。铁氧化物纳米颗粒（NPs），特别是Fe304纳米颗粒，具有许多适当的特性，使它们成为药物输送的可行选择。
• US9849193B2
  申请人：——

  公开号：US9849193B2

  公开（公告）日：2017-12-26