3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid | 428815-57-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid
• 英文别名: 3-[[4-[[N-[(3-acetylphenyl)carbamoyl]-4-cyclohexylanilino]methyl]benzoyl]amino]propanoic acid
• CAS: 428815-57-0
• 化学式: C₃₂H₃₅N₃O₅
• 分子量: 541.647
• InChiKey: ZIDXISBAJADYIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Glucagon antagonists/inverse agonists
  申请人：——

  公开号：US20030065031A1

  公开（公告）日：2003-04-03

  Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.

  新化合物，其作用是拮抗胰高血糖素对胰高血糖素受体的作用。由于它们对胰高血糖素受体的拮抗作用，这些化合物可能适用于治疗和/或预防任何疾病和紊乱，其中胰高血糖素拮抗作用是有益的，如高血糖症、1型糖尿病、2型糖尿病、脂质代谢紊乱和肥胖症。
• US6706744B2
  申请人：——

  公开号：US6706744B2

  公开（公告）日：2004-03-16
• [EN] GLUCAGON ANTAGONISTS/INVERSE AGONISTS<br/>[FR] ANTAGONISTES/AGONISTES INVERSES DE GLUCAGON
  申请人：NOVO NORDISK AS

  公开号：WO2002040444A1

  公开（公告）日：2002-05-23

  Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.