ethyl 2-(4-((3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2-fluorophenoxy)-2-methylpropanoate hydrochloride | 1041609-71-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: ethyl 2-(4-((3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2-fluorophenoxy)-2-methylpropanoate hydrochloride
• 英文别名: ethyl 2-[4-[[[3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidine-2-carbonyl]amino]methyl]-2-fluorophenoxy]-2-methylpropanoate;hydrochloride
• CAS: 1041609-71-5
• 化学式: C₂₇H₃₁F₄N₃O₅S*ClH
• 分子量: 622.081
• InChiKey: IGVOZGSEBUCZGF-FPDMAROZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.86
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF
  申请人：Kim Sung Soo

  公开号：US20100048570A1

  公开（公告）日：2010-02-25

  The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a β-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.

  本发明涉及具有β-氨基团的酰基链上的新型2-羰基-3-酰基-1,3-噻唑啉化合物，包括其自由形式、前药形式或其药用可接受盐，包括它们的对映体、异构体和消旋体，作为高效的DPP-IV抑制剂。该发明还涉及包含所述化合物的药物组合物。本发明还涉及制备所述化合物以及治疗DPP-IV介导的疾病的方法。
• Process for producing array plate for biomolecules having hydrophilic and hydrophobic regions
  申请人：SAMSUNG ELECTRONICS CO., LTD.

  公开号：EP1364702A2

  公开（公告）日：2003-11-26

  A method for manufacturing an array plate for biomolecules and a method for manufacturing a biochip using this array plate are provided. The array plate manufacturing method includes: (a) coating a surface of a substrate (1) with a hydrophobic material to form a hydrophobic layer (3); (b) etching the hydrophobic layer through an etch mask (4) placed thereon to form a hydrophilic binding site (5); (c) removing the remaining etch mask; and (d) processing the remaining region of the hydrophobic layer (3) to recover its original hydrophobic properties. The biochip manufacturing method includes processing the surface of the hydrophilic binding site (5) of an array plate manufactured using the method, and applying a solution containing biomolecules to the surface of the hydrophilic binding site.

  本发明提供了一种制造生物大分子阵列板的方法和一种使用该阵列板制造生物芯片的方法。阵列板制造方法包括(a) 用疏水材料涂覆基底 (1) 的表面，形成疏水层 (3)；(b) 通过放置在其上的蚀刻掩膜 (4) 蚀刻疏水层，形成亲水结合位点 (5)；(c) 去除剩余的蚀刻掩膜；以及 (d) 处理疏水层 (3) 的剩余区域，以恢复其原有的疏水特性。生物芯片制造方法包括处理使用该方法制造的阵列板的亲水结合部位（5）的表面，并将含有生物分子的溶液涂抹到亲水结合部位的表面。
• Method and apparatus for conducting an array of chemical reactions on a support surface
  申请人：Brennan M. Thomas

  公开号：US20050009092A1

  公开（公告）日：2005-01-13

  The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods of sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromolecules, by specifically binding biologically active macromolecules to arrays of peptides or peptide mimetics.

  本发明提供了在支撑表面上制作功能化结合位点阵列的装置和方法。本发明进一步提供了寡核苷酸测序的装置和方法，以及通过将生物活性大分子与肽或肽模拟物阵列特异性结合，鉴定与生物活性大分子结合的肽的氨基酸序列的装置和方法。
• METHOD AND APPARATUS FOR CONDUCTING AN ARRAY OF CHEMICAL REACTIONS ON A SUPPORT SURFACE
  申请人：PROTOGENE LABORATORIES, INC.

  公开号：EP0703825B1

  公开（公告）日：1997-07-30
• METHODS AND COMPOSITIONS FOR ECONOMICALLY SYNTHESIZING AND ASSEMBLING LONG DNA SEQUENCES
  申请人：Protogene Laboratories, Inc.

  公开号：EP1159285A1

  公开（公告）日：2001-12-05