7-[5-[bis(2-chloroethyl)amino]-1-ethylbenzimidazol-2-yl]-N-hydroxyheptanamide | 1236199-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 7-[5-[bis(2-chloroethyl)amino]-1-ethylbenzimidazol-2-yl]-N-hydroxyheptanamide
• CAS: 1236199-59-9
• 化学式: C₂₀H₃₀Cl₂N₄O₂
• 分子量: 429.39
• InChiKey: OIKVCJRHBGSKGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL COMPOSITION COMPRISING AN HDAC INHIBITOR AND A CYCLOPOLYSACCHARIDE
  申请人：EURO-CELTIQUE S.A.

  公开号：EP3318284A1

  公开（公告）日：2018-05-09

  The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X1, X2, Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.

  本发明涉及药物组合物，包括：(a) 环多糖和 (b) 式 (I) 化合物或其药物可接受盐： 其中 X1、X2、Q、Z 和 m 在本文中定义。还公开了一种用这些组合物治疗肿瘤性疾病或免疫性疾病的方法。
• Pharmaceutical composition comprising an HDAC inhibitor and a cyclopolysaccharide
  申请人：EURO-CELTIQUE S.A.

  公开号：EP2758052B1

  公开（公告）日：2018-02-14
• Hydroxamic Acid Derivatives
  申请人：Chen Yu

  公开号：US20110269706A1

  公开（公告）日：2011-11-03

  The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.
• HYDROXAMIC ACID DERIVATIVES
  申请人：Purdue Pharmaceutical Products L.P.

  公开号：US20140066419A1

  公开（公告）日：2014-03-06

  The present invention is directed to a method of alleviating, relieving, altering, remedying, ameliorating, improving or affecting a neoplastic disease or an immune disease, the method comprising administering to a subject in need thereof an effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein P, Z, and m are defined herein above.
• Pharmaceutical Compositions
  申请人：Chen Yu

  公开号：US20150183747A1

  公开（公告）日：2015-07-02

  The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X 1 , X 2 , Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.