6-hydroxyhexyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside 6-hydrogensulfate | 188176-89-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-hydroxyhexyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside 6-hydrogensulfate
• CAS: 188176-89-8
• 化学式: C₁₈H₃₀O₁₂S
• 分子量: 470.495
• InChiKey: KXPIIONDPHZBNB-XRVCTDEGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.92
• 重原子数：
  31.0
• 可旋转键数：
  12.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  160.96
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  6-hydroxyhexyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside 6-hydrogensulfate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以72%的产率得到6-hydroxyhexyl β-L-fucopyranoside 6-hydrogensulfate
  参考文献：
  名称：

  Synthesis of Sialyl Lewis x Analogues 2

  摘要：

  Sialyl Lewis X (SLe(X) analogues) containing beta-1-fucopyranosyl residues with an alkyl [-(CH2)(6)-] (1a), a heteroalkyl [-(CH2)(2)-O-(CH2)(3)-] (Ib)or a heterocycloalkyl [-2-cyclohexyl-O-(CH,),-] (2a) moiety were synthesised by silver ion promoted glycosylation. Further analogues where sialic acid was replaced by a second beta-L-fucopyranosyl (3a, 3b) or hydrogensulphate unit (4a, 4b) were also prepared.

  DOI：

  10.1080/07328309708006507
• 作为产物：
  描述：

  1,6-己二醇 在 吡啶 、 氯磺酸 、 silver salicylate 作用下， 以 氯仿 为溶剂， 反应 27.0h， 生成 6-hydroxyhexyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside 6-hydrogensulfate
  参考文献：
  名称：

  Synthesis of Sialyl Lewis x Analogues 2

  摘要：

  Sialyl Lewis X (SLe(X) analogues) containing beta-1-fucopyranosyl residues with an alkyl [-(CH2)(6)-] (1a), a heteroalkyl [-(CH2)(2)-O-(CH2)(3)-] (Ib)or a heterocycloalkyl [-2-cyclohexyl-O-(CH,),-] (2a) moiety were synthesised by silver ion promoted glycosylation. Further analogues where sialic acid was replaced by a second beta-L-fucopyranosyl (3a, 3b) or hydrogensulphate unit (4a, 4b) were also prepared.

  DOI：

  10.1080/07328309708006507