silver salicylate | 14800-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: silver salicylate
• 英文别名: silver(I) salicylate；Silbersalicylat；silver;2-hydroxybenzoate
• CAS: 14800-64-7
• 化学式: Ag*C₇H₅O₃
• 分子量: 244.983
• InChiKey: QOVGHSPSIUCXQC-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.25
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  silver salicylate 在 三苯基膦 作用下， 以 苯 为溶剂， 生成 [Ag(O2CC4H4OH-o)(PPh3)3]
  参考文献：
  名称：

  第1B组的金属络合物。第1部分。三苯基膦银（I）羧酸盐

  摘要：

  已经研究了羧酸与Ag I的配位方式。通过对1 H nmr和ir光谱以及溶液分子量的研究，络合物中的银原子都是四坐标的，但化学计量学取决于酸的p K a。所有被研究的stoicheiometry形成复合物将[Ag（O酸2 CR）（PPH 3）2 ]（R = Me中，CH 2氯，三氯甲烷2中，Ph，C 6 H ^ 4 ME- ø，C 6 H ^ 4 ME-米或C 6 H 4 OH-o）。此外，对于具有p酸ķ一个> 3.9（即R =我中，Ph，C 6 H ^ 4 ME- Ò，或C 6 H ^ 4 ME-米）的酸到银结果在复杂storcheiometry的螯合[ Ag（O 2 CR）（PPh 3）2 ]。所研究的两种二元酸，己二酸和丙二酸，显示出相似的p K a依赖性。

  DOI：

  10.1039/dt9770002068
• 作为产物：
  描述：

  silver nitrate 、 阿司匹林 在 NH₃ 、 H₂O 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 silver salicylate
  参考文献：
  名称：

  Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic acid

  摘要：

  Two new mixed ligand silver(I) complexes of formulae {[Ag(tpp)(3)(asp)](dmf)} (1) (aspH = o-acetylsalicylic acid and tpp = triphenylphosphine) and [Ag(tpp)(2)(o-Hbza)] (2) (o-HbzaH = o-hydroxy-benzoic acid) were synthesized and characterized by elemental analyses, spectroscopic techniques and X-ray crystallography at ambient conditions. Three phosphorus and one carboxylic oxygen atoms from a de-protonated aspirin ligand in complex 1 and two phosphorus and two carboxylic oxygen atoms from a chelating o-Hbza anion in complex 2 form a tetrahedral geometry around Ag(I) ions in both complexes.Complexes 1 and 2 and the silver(I) nitrate, tpp, aspNa and o-HbzaH were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS), human breast adenocarcinoma cells (MCF-7) and normal human fetal lung fibroblasts (MRC-5) cells with Thiazolyl Blue Tetrazolium Bromide (MTT) assay. For both cell lines 1 and 2 were found to be more active than cisplatin. Additionally, 1 and 2 exhibit lower activity on cell growth proliferation of MRC-5 cells. The type of LMS cell death caused by 1 and 2 were evaluated in vitro by use of flow cytometry assay. The results show that at concentrations of 1.5 and 1.9 mu M of complex 1, 44.1% and 69.4%, respectively of LMS cells undergo programmed cell death (apoptosis). When LMS cells were treated with 1.6 and 2.3 mu M of 2, LMS cells death was by 29.6% and 81.3%, respectively apoptotic. Finally, the influence of the complexes 1 and 2, upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The binding of 1 and 2 towards LOX was also investigated by Saturation Transfer Difference (STD) H-1 NMR experiments. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.04.032
• 作为试剂：
  描述：

  1,6-己二醇 、 2-哌啶羧酸,4,4-二羟基-,(2S)- 在 silver salicylate 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以83%的产率得到6-hydroxyhexyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside
  参考文献：
  名称：

  Synthesis of Sialyl Lewis x Analogues 2

  摘要：

  Sialyl Lewis X (SLe(X) analogues) containing beta-1-fucopyranosyl residues with an alkyl [-(CH2)(6)-] (1a), a heteroalkyl [-(CH2)(2)-O-(CH2)(3)-] (Ib)or a heterocycloalkyl [-2-cyclohexyl-O-(CH,),-] (2a) moiety were synthesised by silver ion promoted glycosylation. Further analogues where sialic acid was replaced by a second beta-L-fucopyranosyl (3a, 3b) or hydrogensulphate unit (4a, 4b) were also prepared.

  DOI：

  10.1080/07328309708006507

文献信息

• Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid: Enhancement of their solubility and bioactivity by using the surfactant CTAB
  作者：E.I. Gkaniatsou、C.N. Banti、N. Kourkoumelis、S. Skoulika、M. Manoli、A.J. Tasiopoulos、S.K. Hadjikakou

  DOI：10.1016/j.jinorgbio.2015.04.014

  日期：2015.9

  The already known Ag(I)-Sb(III) compound of the formula Ag(Ph3Sb)3(NO3)} (1) and two novel mixed metal Ag(I)-Sb(III) metallotherapeutics of the formulae Ag(Ph3Sb)3(SalH)}(2) and Ag(Ph3Sb)3(Asp)}(3) (SalH2 = salicylic acid, AspH = aspirin or 2-acetylsalicylic acid and Ph3Sb = triphenyl antimony(III)) have been synthesised and characterised by m.p., vibrational spectroscopy (mid-FT-IR), 13C-,1H-NMR

  式Ag（Ph 3 Sb）3（NO 3）}（1）的已知Ag（I）-Sb（III）化合物和该通式的两种新型混合金属Ag（I）-Sb（III）金属治疗剂Ag（Ph 3 Sb）3（SalH）}（2）和Ag（Ph 3 Sb）3（Asp）}（3）（SalH 2  =水杨酸，AspH =阿司匹林或2-乙酰基水杨酸和Ph 3 Sb =已合成并通过mp，振动光谱法（mid-FT-IR），13 C-，1表征三苯基锑（III）H-NMR，UV-可见（UV-vis）光谱技术，高分辨率质谱（HRMS）和X射线晶体学。化合物1，- 3用表面活性剂十六烷基三甲基铵（CTAB），以便增强它们的溶解性并因此它们的生物活性治疗。所得的胶束a–c的特征在于X射线粉末衍射（XRPD）分析，X射线荧光（XRF）光谱，能量色散X射线光谱（EDX），电导率，热重分析–差示热分析（TG– DTA）和原子吸收。化合物1 - 3和有关
• Untersuchungen zur Glykosidsynthese, V. Reaktionsprodukte und Stereospezifität der Glucosylierung in Gegenwart unlöslicher Silbersalze in Diäthyläther
  作者：Günter Wulff、Gerhard Röhle、Ulrich Schmidt

  DOI：10.1002/cber.19721050404

  日期：1972.4

  -α-D-glucopyranoside (z. B. 2b und 5a) auf. Die Umsetzung zum 2.3.4.6-Tetra-O-acetyl-β-D-glucopyranosid verläuft stereospezifisch. Auch Verbindungen mit nicht zur Nachbargruppenbeziehung befähigten Gruppen, wie die beiden anomeren Bromide 9 und 10, liefern unter Walden-Inversion die Glykoside von jeweils entgegengesetzter Konfiguration. Inversion wurde auch beim Einsatz von L-1-Methyl-heptylbromid anstelle einer

  Beige der Umsetzung vonα-乙酰溴葡萄糖（z。B. Cholesterin）位于Gegenwart von Silber-4-hydroxy-valerat的Diäthyläther，von Ag 2 O oder von Ag 2 CO 3分布于AllenFällenneben dem entsprechenden 2.3.4.6-四ø乙酰基β-d-glucopyranosid（żB. 2A中geringerer猛恶）模具Alkoholacetate（Z B. Cholesterinacetat。），模具原酸酯（Z B.。4 UND死3.4.6三- ）ö -乙酰-β-和-α-D-吡喃葡萄糖苷（z。B. 2b和5a）auf。Die Umsetzung zum 2.3.4.6-Tetra- O-乙酰基-β-D-吡喃葡萄糖苷立体异构体。由Nupbargruppenbezi
• Antimicrobial polymer compositions and the use thereof
  申请人：Emeta Modesto

  公开号：US20060263330A1

  公开（公告）日：2006-11-23

  An antimicrobial composition comprising: a complex of an anionic polyester with an antimicrobial metal wherein the anionic polyester has at least one carboxylic acid group. A medical device having an antimicrobial composition comprising: a complex of an anionic polyester with an antimicrobial metal wherein the anionic polyester has at least one carboxylic acid group.

  一种抗菌组合物，包括：一种阴离子聚酯与一种含有至少一个羧酸基团的抗菌金属的复合物。包括抗菌组合物的医疗器械，其中该抗菌组合物包括：一种阴离子聚酯与一种含有至少一个羧酸基团的抗菌金属的复合物。
• Antimicrobial Amorphous Compositions
  申请人：Karandikar M. Bhalchandra

  公开号：US20070254044A1

  公开（公告）日：2007-11-01

  The present invention comprises compositions and methods for providing antimicrobial compositions. The antimicrobial compositions comprise gel delivery vehicles comprising stabilized silver, wherein ionic silver is provided to a site for antimicrobial purposes. Methods of making and using such compositions are taught, including application of the silver-containing gel compositions to wounds, burns, abrasions, cuts, surgical incision, sites where skin or organ integrity has been breached, and other sites to supply an antimicrobial environment.

  这项发明涉及提供抗菌组合物的组合物和方法。抗菌组合物包括含有稳定银的凝胶传递载体，其中提供离子银以用于抗菌目的。教授了制备和使用这种组合物的方法，包括将含银凝胶组合物应用于伤口、烧伤、擦伤、切口、手术切口、皮肤或器官完整性受损的部位以及其他部位，以提供抗菌环境。
• [EN] ANTIMICROBIAL COMPOSITIONS AND METHODS OF MAKING THE SAME<br/>[FR] COMPOSITIONS ANTIMICROBIENNES ET LEURS PROCÉDÉS DE FABRICATION
  申请人：KARANDIKAR BHALCHANDRA M

  公开号：WO2014179353A1

  公开（公告）日：2014-11-06

  The present disclosure comprises antimicrobial compositions and devices comprising silver compounds that resist heat and light discoloration. In one aspect, the said compounds comprise silver and at least one s-triazine ring or moiety. In another aspect, the antimicrobial compositions are hydrogels that are effective against broad spectrum of common pathogens including MRSA and VRE and are suitable for treating human or animal wounds and burns. The methods of the present disclosure comprise treating medical and non-medical devices and articles with compositions comprising the silver compounds to impart antimicrobial property.

  本公开涵盖了含有抗菌成分和含有抗热和抗光变色的银化合物的器械。在一个方面，所述化合物包括银和至少一个s-三嗪环或基团。在另一个方面，抗菌成分是对抗包括MRSA和VRE在内的常见病原体广谱有效的水凝胶，适用于治疗人类或动物的伤口和烧伤。本公开的方法包括使用含有银化合物的组合物处理医疗和非医疗器械和物品，以赋予其抗菌性能。