1-(5-Methoxypyridin-2-yl)propan-1-one | 1566456-87-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(5-Methoxypyridin-2-yl)propan-1-one
• CAS: 1566456-87-8
• 化学式: C₉H₁₁NO₂
• mdl: MFCD26047760
• 分子量: 165.19
• InChiKey: JRLHWZAIPCZJKU-UHFFFAOYSA-N

物化性质

• 沸点：
  282.5±20.0 °C(Predicted)
• 密度：
  1.067±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• BENZAMIDE INHIBITORS OF BACTERIAL LIPOPROTEIN SIGNAL PEPTIDASE
  申请人：The Scripps Research Institute

  公开号：US20200181101A1

  公开（公告）日：2020-06-11

  Increasing resistance to antibiotics necessitates discovery of new targets and strategies to combat bacteria. Ideal protein targets are required for viability across many species, are unique to prokaryotes to limit effects on the host and have robust assays to quantitate activity and identify novel inhibitors. Lipoprotein signal peptidase (Lsp) is a transmembrane aspartyl protease required for lipoprotein maturation and entirely fits these criteria. We have developed the first in vitro high-throughput assay to monitor proteolysis by Lsp. We employed our HTS assay against 646,275 compounds to discover inhibitors of Lsp and synthesized a range of analogues to generate molecules with nanomolar IC50 values. Importantly, our inhibitors are effective in preventing the growth of E. coli cultures. Our Lsp assay will be a useful tool for biologists to monitor Lsp activity and our inhibitors will facilitate development of antibacterial agents to potentially treat antibiotic-resistant bacteria.
• HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
  申请人：Nuvation Bio Inc.

  公开号：US20210292285A1

  公开（公告）日：2021-09-23

  Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.