1-Phenyl-3-methyl-5-(4-methylphenylthio)-4-pyrazolaldoxime | 908287-69-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Phenyl-3-methyl-5-(4-methylphenylthio)-4-pyrazolaldoxime
• 英文别名: N-[[3-methyl-5-(4-methylphenyl)sulfanyl-1-phenylpyrazol-4-yl]methylidene]hydroxylamine
• CAS: 908287-69-4
• 化学式: C₁₈H₁₇N₃OS
• 分子量: 323.418
• InChiKey: ZVTHSYPQCKKNOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  75.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氯-5-氯甲基吡啶 、 1-Phenyl-3-methyl-5-(4-methylphenylthio)-4-pyrazolaldoxime 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.34h， 以81%的产率得到1-phenyl-3-methyl-5-(4-methylphenylthio)-4-pyrazolaldoxime-(2-chloropyridine-5-ylmethyl) ether
  参考文献：
  名称：

  Synthesis and Antiviral Activities of Pyrazole Derivatives Containing an Oxime Moiety

  摘要：

  Target compounds 4a-n were obtained by the reaction of 1-substituted phenyl-3-methyl-5-substituted phenylthio-4-pyrazolaidoximes (3) with chloromethylated heterocyclic compounds (CICH2-R-3) under reflux conditions in ethanol. Subsequently, the oxidation of 4a-e with KMnO4 in HOAc at room temperature afforded eight new compounds, 5a-h. The synthesized compounds were characterized by physical constants, and the structures of the title compounds were confirmed by IR, H-1 NMR, C-13 NMR, and elemental analysis. The bioassay revealed that the compounds possessed antiviral activities. It was found that title compounds 4a and 4g had the same inactivation effects against TMV (EC50 = 58.7 and 65.3 mu g/mL) as the commercial product Ningnanmycin (EC50 = 52.7 mu g/mL). To the best of our knowledge, this is the first report on the antiviral activity of pyrazole derivatives containing an oxime moiety.

  DOI：

  10.1021/jf802489e
• 作为产物：
  描述：

  3-methyl-1-phenyl-5-(p-tolylthio)-1H-pyrazole-4-carbaldehyde 在 盐酸羟胺 作用下， 生成 1-Phenyl-3-methyl-5-(4-methylphenylthio)-4-pyrazolaldoxime
  参考文献：
  名称：

  含肟酯基的新型吡唑衍生物的合成及抗病毒活性。

  摘要：

  通过用酰氯处理，由起始原料1-取代苯基-3-甲基-5-取代苯硫基-4-吡唑醛肟3合成14个标题化合物，即1-取代-5-取代苯硫基-4-吡唑并肟肟酯衍生物4a-4n。通过物理常数表征合成的化合物，并通过IR，1 H NMR，13 C NMR和元素分析进一步证实标题化合物的结构。生物测定结果表明标题化合物具有弱到良好的抗TMV生物活性，其中4l具有对TMV CP的高亲和力，显着增强了烟叶的抗病性。

  DOI：

  10.1016/j.bmc.2008.09.070