4-(3-Bromo-2-hydroxypropyl)-4-hydroxycyclohexanone | 1056881-40-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(3-Bromo-2-hydroxypropyl)-4-hydroxycyclohexanone
• 英文别名: 4-(3-bromo-2-hydroxypropyl)-4-hydroxycyclohexan-1-one
• CAS: 1056881-40-3
• 化学式: C₉H₁₅BrO₃
• 分子量: 251.12
• InChiKey: RIMNUUSPUJLFGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Oligomer-Opioid Agonist Conjugates
  申请人：Riggs-Sauthier Jennifer

  公开号：US20100048602A1

  公开（公告）日：2010-02-25

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  该发明提供了通过共价连接水溶性寡聚体进行化学修饰的化合物。该发明的化合物在通过任何一种给药途径给予时，表现出与未连接水溶性寡聚体的化合物不同的特性。
• OLIGOMER-OPIOID AGONIST CONJUGATES
  申请人：RIGGS-SAUTHIER Jennifer

  公开号：US20120289548A1

  公开（公告）日：2012-11-15

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  该发明提供了通过共价连接水溶性寡聚体进行化学修饰的化合物。 该发明的化合物在通过任何一种给药途径给予时，表现出与未连接水溶性寡聚体的化合物不同的特性。
• PEG oligomer-fentanyl conjugates
  申请人：Nektar Therapeutics

  公开号：EP2628489A1

  公开（公告）日：2013-08-21

  This invention provides conjugates wherein the opioid agonist fentanyl is covalently attached to poly(ethylene glycol) oligomers. A conjugate of the invention when administered by any of a number of administration routes, exhibits characteristics that are different from those of the opioid agonist not attached to the PEG oligomers.

  本发明提供了阿片类激动剂芬太尼与聚乙二醇低聚物共价连接的共轭物。本发明的共轭物在通过多种给药途径中的任何一种给药时，都会表现出与未附着在聚乙二醇低聚物上的阿片类激动剂不同的特性。
• Oligomer-opioid agonist conjugates
  申请人：Nektar Therapeutics

  公开号：EP2623123A1

  公开（公告）日：2013-08-07

  The invention provides an opioid agonist compound that is chemically modified by covalent attachment of a water-soluble oligomer. The compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the opioid agonist compound not attached to the water-soluble oligomer.

  本发明提供了一种通过共价连接水溶性低聚物进行化学修饰的阿片类激动剂化合物。本发明的化合物在通过多种给药途径中的任何一种给药时，会表现出不同于未附着水溶性低聚物的阿片类受体激动剂化合物的特性。
• US8173666B2
  申请人：——

  公开号：US8173666B2

  公开（公告）日：2012-05-08