ethyl 2,3-di-O-acetyl-α-D-ribofuranoside | 1252113-77-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2,3-di-O-acetyl-α-D-ribofuranoside
• CAS: 1252113-77-1
• 化学式: C₁₁H₁₈O₇
• 分子量: 262.26
• InChiKey: NCXGYBUXPLPIIX-DBIOUOCHSA-N

反应信息

• 作为产物：
  描述：

  ethyl 2,3,5-tri-O-acetyl-D-ribofuranoside 在 Candida antarctica B lipase 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 ethyl 2,3-di-O-acetyl-β-D-ribofuranoside 、 ethyl 2,3-di-O-acetyl-α-D-ribofuranoside
  参考文献：
  名称：

  Candida antarcticaB lipase-catalysed alcoholysis of peracetylated alkyl D-ribofuranosides

  摘要：

  Candida antarctica B lipase (CAL-B) catalysed alcoholysis of a series of peracetylated alkyl alpha, beta-D-ribofuranosides was assayed. Methyl and ethyl 2,3-di-O-acetyl-alpha, beta-D-ribofuranosides enriched in the alpha-anomer were regioselectively prepared through this enzymatic deacetylation in 33% and 43% yield, respectively, the latter being a new compound. Isopropyl 2,3,5-tri-O-acetyl-beta-D-ribofuranoside gave the new isopropyl 2,3-di-O-acetyl-beta-D-ribofuranoside in 24% yield. The anomeric substituent affects the regioselectivity of the reaction, since n-propyl and n-butyl alpha, beta-D-ribofuranosides reacted without selectivity.

  DOI：

  10.3109/10242422.2010.501105